E R SQUIBB MEDATOPE DIV -- 0015-3213-30 PARAPLATIN (CARBOPLATIN FOR INJECTION) 50 MG  -- 6505-01-308-8071
<pre>=====================  Product Identification  =====================

Product ID:0015-3213-30 PARAPLATIN (CARBOPLATIN FOR INJECTION) 50 MG
MSDS Date:01/07/1993
FSC:6505
NIIN:01-308-8071
MSDS Number: CDCLJ
=== Responsible Party ===
Company Name:E R SQUIBB MEDATOPE DIV
Address:5 GORDIS RD BLDG 124
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903-5000
Country:US
Info Phone Num:800-332-2056/908-519-3843
Emergency Phone Num:908-519-3843/609-921-4081
CAGE:GO533
=== Contractor Identification ===
Company Name:E R SQUIBB MEDATOPE DIV
Address:5 GORDIS RD  BLDG 124
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Phone:609-921-4081
CAGE:4T649
Company Name:E R SQUIBB MEDATOPE DIV
Address:5 GORDIS RD BLDG 124
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903-5000
Country:US
Phone:800-332-2056/908-519-3843
CAGE:GO533

=============  Composition/Information on Ingredients  =============

Ingred Name:PLATINUM, DIAMMINE [1,1-CYCLOBUTANE-DICARBOXYLATO
    (2-)-O,0']
CAS:41575-94-4
RTECS #:TP2300000
Fraction by Wt: 50%

Ingred Name:MINNITOL, D- (MANNA SUGAR); MANNITOL
CAS:69-65-8
RTECS #:OP2060000
Fraction by Wt: >1%

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50(RAT): 343 MG/KG
Routes of Entry: Inhalation:YES  Skin:NO  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:CARBOPLATIN IS TOXIC AFTER ACUTE
    INGESTION. INHALATION: TRANSIENT BRONCHIAL IRRITATION MAY OCCUR.
    EYES: MATERIAL MAY CAUSE CONJUNCTIVITIS. AFTER SYSTEMIC INJECTION,
    MAY CAUSE ANAPHYLACTOID REACTIONS.	SIDE EFFECT MAY INCLUDE:
    REVERSIBLE BLOOD EFFECTS, HEPATIC TOXICITY, KIDNEY ABNORMALITIES &
    ELECTROLYTE LOSS.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:IRRITATION, RASH, NAUSEA, VOMITING, WHEEZING,
    RESPIRATORY DIFFICULTY, HYPOTENSION, RINGING OF THE EARS, HEARING
    LOSS
Medical Cond Aggravated by Exposure:KIDNEY DISEASE, HEARING DISORDERS,
    NEUROLOGICAL DISEASES, ANEMIA/OTHER FORMS OF BONE MARROW
    SUPPRESSION.

=======================  First Aid Measures  =======================

First Aid:INGESTION: INDUCTION OF VOMITING, IF PERSON IS CONSCIOUS &
    NOT EXPERIENCING CONVULSIONS. NEVER GIVE ANYTHING BY MOUTH IF
    UNCONSCIOUS. INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF
    NECESSARY. SKI N: IMMEDIATELY FLUSH W/LARGE AMOUNTS OFWATER. USE
    SOAP IF AVAILABLE. EYES: FLUSH W/RUNNING WATER FOR 15 MINS. OBTAIN
    MEDICAL ATTENTION IN ALL CASES. PRODUCT CONTAINS A CYTOTOXIC
    ANTINEOPLASTIC DRUG.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:FLOOD W/WATER
Fire Fighting Procedures:WEAR SCBA, FLAME & CHEMICAL RESISTANT
    CLOTHING, BOOTS, GLOVES. EVACUATE PERSONNEL TO UPWIND DIRECTION.
    COOL CONTAINERS W/WATER FROM A MAXIMUM DISTANCE.
Unusual Fire/Explosion Hazard:FINE POWDERS ARE CONSIDERED TO BE
    COMBUSTIBLE.

==================  Accidental Release Measures  ==================

Spill Release Procedures:SMALL: WIPE LIQUIDS W/ABSORBENT GAUZE PADS.
    CLEAN W/DETERGENT & WATER. COVER POWDER W/GAUZE PAD/PAPER TOWEL.
    SOAK W/WATER, WIPE UP W/DETERGENT & WATER. LARGE: COVER LIQUID
    W/ABSORBENT SHEETS/CONTROL P ADS/PILLOWS. COVER W/DAMP
    CLOTH/TOWELS.(SEE SUPP)

======================	Handling and Storage  ======================

Handling and Storage Precautions:STORE AT ROOM TEMP 59F-77F. DON'T
    REFRIGERATE. PROTECT FROM LIGHT. DON'T BREAK VIALS/SPILL CONTENTS.
    DON'T ALLOW PARAPLATIN TO CONTACT ALUMINUM.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WHEN ENGINEERING CONTROLS AREN'T SUFFICIENT TO
    CONTROL EXPOSURE, WEAR APPROVED DUST RESPIRATOR W/HIGH EFFICIENCY
    DUST FILTER/POWDERED AIR-PURIFYING RESPIRATOR; SELF CONTAINED
    BREATHING APPARATUS.
Ventilation:LOCAL MECHANICAL EXHAUST VENTILATION TO MINIMIZE EMPLOYEE
    EXPOSURE.
Protective Gloves:DISPOSABLE SURGICAL LATEX
Eye Protection:CHEMICAL SAFETY GOGGLES (ANZI Z87.1)
Other Protective Equipment:IMPERVIOUS DISPOSABLE OVERALLS W/CLOSED
    FRONT, LONG SLEEVES, ELASTIC CUFFS, BOOTS.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING & SHOES
    BEFORE REUSE.
Supplemental Safety and Health
PH: 5-7 (1% SOLUTION). SPILL PROC CONT'D: LARGE: CLEAN USING DETERGENTS
    & WATER. GLOVES SHOULD BE CHANGED REGULARLY & REMOVED IMMEDIATELY
    AFTER OVERT CONTAMINATION. DOUBLE GLOVING IS RECOMMENDED. WASH 
    HANDS, FOREARMS & FACE THOROUGHLY AFTER HANDLING & BEFORE EATING,
    SMOKING, USING LAVATORY & AT THE END OF DAY.

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:M.P/F.P Text:>446F
pH:(SUPP)
Solubility in Water:14 MG/ML
Appearance and Odor:WHITE LYOPHILIZED POWDER WHICH IS PACKAGED IN
    VIALS.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
FORMATION OF A PLATINUM PRECIPITATE WHEN PARAPLATIN COMES IN CONTACT
    W/ALUMINUM.
Stability Condition to Avoid:LIGHT
Hazardous Decomposition Products:CO, CARBON OXIDES, NITROGEN OXIDES

====================  Disposal Considerations  ====================

Waste Disposal Methods:TREAT PRODUCTS & CONTAMINATED MATERIALS AS A
    HAZARDOUS MATERIAL. INCINERATION AT AN APPROVED FACILITY IS
    RECOMMENDED. DISPOSE OF IAW/LOCAL, STATE & FEDERAL REGULATIONS.

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