E R SQUIBB MEDATOPE DIV -- PLANTINOL 50 MG CISPLATIN/VIAL  -- 6505-01-074-7590
<pre>=====================  Product Identification  =====================

Product ID:PLANTINOL 50 MG CISPLATIN/VIAL
MSDS Date:01/07/1993
FSC:6505
NIIN:01-074-7590
MSDS Number: CDFSN
=== Responsible Party ===
Company Name:E R SQUIBB MEDATOPE DIV
Address:5 GORDIS RD BLDG 124
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903-5000
Country:US
Info Phone Num:800-332-2056/908-519-3843
Emergency Phone Num:908-519-3843/609-921-4081
CAGE:GO533
=== Contractor Identification ===
Company Name:E R SQUIBB MEDATOPE DIV
Address:5 GORDIS RD  BLDG 124
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903
Country:US
Phone:609-921-4081
CAGE:4T649
Company Name:E R SQUIBB MEDATOPE DIV
Address:5 GORDIS RD BLDG 124
Box:191
City:NEW BRUNSWICK
State:NJ
ZIP:08903-5000
Country:US
Phone:800-332-2056/908-519-3843
CAGE:GO533

=============  Composition/Information on Ingredients  =============

Ingred Name:CIS-DIAMINEDICHLOROPLATINUM
CAS:15663-27-1
RTECS #:TP2450000
Fraction by Wt: 5%
OSHA PEL:0.002 MG(PT)/CUM

Ingred Name:MINNITOL, D- (MANNA SUGAR); MANNITOL
CAS:69-65-8
RTECS #:OP2060000
Fraction by Wt: >1%

Ingred Name:SODIUM CHLORIDE		    *96-4*
CAS:7647-14-5
RTECS #:VZ4725000
Fraction by Wt: >1%

Ingred Name:HYDROCHLORIC ACID, HYDROGEN CHLORIDE, MURIATIC ACID        
    HYDROCHLORIDE
CAS:7647-01-0
RTECS #:MW4025000
Other REC Limits:7 PPM
OSHA PEL:5 PPM
ACGIH TLV:C 11 MG/CUM
EPA Rpt Qty:5000 LBS
DOT Rpt Qty:5000 LBS

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:ORAL LD50(RAT): 25.8 MG/KG
Routes of Entry: Inhalation:NO	Skin:NO  Ingestion:NO
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:CISPLATIN-A CYTOTOXIC DRUG.
    INHALATION: TRANSIENT BRONCHIAL IRRITANT. SKIN: FROM OPENED VIAL;
    MILD IRRITANT. EYES: CONJUNCTIVITIS. INTRAVENOUS EXPOSURE MAY CAUSE
    ANAPHYLACTOID REACTIONS. MAY CAUSE KID NEY TOXICITY/PERIPHERAL
    NEUROPATHY/REVERSIBLE HEMATOLOGIC EFFECTS. POTENTIAL
    CARCINOGEN/TERATOGEN/REPRODUCTIVE EFFECTOR.
Explanation of Carcinogenicity:NONE
Effects of Overexposure:CISPLATIN: IRRITATION, RASH, NAUSEA, VOMITING,
    FACIAL EDEMA, FLUSHING, WHEEZING, RESPIRATORY DIFFICULTY,
    TACHYCARDIA, HYPOTENSION, ELECTROLYTE DISTURBANCES, OTOTOXICITY
Medical Cond Aggravated by Exposure:KIDNEY DISEASES, HEARING DISORDERS,
    NEUROLOGICAL DISEASES & ANEMIA/OTHER FORMS OF BONE MARROW
    SUPPRESSION.

=======================  First Aid Measures  =======================

First Aid:INGESTION: INDUCE VOMITING IF CONSCIOUS & NOT CONVULSIVE.
    NEVER GIVE ANYTHING BY MOUTH IF UNCONSCIOUS. INHALATION: REMOVE TO
    FRESH AIR. GIVE CPR/OXYGEN IF NECESSARY. SKIN: IMMEDIATELY FLUSH
    W/LARGE AM OUNTS OF WATER. USE SOAP. EYES: FLUSH W/RUNNING WATER
    FOR 15 MINS. OBTAIN MEDICAL ATTENTION IN ALL CASES.

=====================  Fire Fighting Measures  =====================

Extinguishing Media:UNLIKELY TO BURN IN VIAL. IN CASE OF FIRE, FLOOD
    W/WATER
Fire Fighting Procedures:WEAR SCBA, FLAME & CHEMICAL RESISTANT
    CLOTHING, BOOTS & GLOVES. EVACUATE PERSONNEL TO UPWIND. COOL
    CONTAINERS W/WATER FROM A MAXIMUM DISTANCE.

==================  Accidental Release Measures  ==================

Spill Release Procedures:SMALL: WIPE W/ABSORBENT GAUZE PADS. CLEAN
    USING DETERGENT & WATER. COVER W/GAUZE PADS/PAPER TOWEL. SOAK
    W/WATER & WIPE UP. LARGE: COVER LIQUID W/ABSORBENT
    SHEETS/SPILL-CONTROL PADS/PILLOWS. CLEAN USIN G DETERGENTS & WATER.

======================	Handling and Storage  ======================

Handling and Storage Precautions:SHOULD BE STORED AT ROOM TEMP 59-77F.
    DON'T REFRIGERATE. PROTECT FROM LIGHT. SEE RELEVANT GUIDANCE FOR
    HANDLING CYTOTOXIC MATERIALS.
Other Precautions:DON'T ALLOW PLATINOL TO CONTACT ALUMINUM. ALUMINUM
    REACTS W/FORMULATED PLATINOL, CAUSING PRECIPITATE FORMATION & LOSS
    OF POTENCY.

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:WHEN ENGINEERING CONTROLS AREN'T SUFFICIENT TO
    CONTROL EXPOSURE, WEAR APPROVED RESPIRATOR W/HIGH EFFICIENCY DUST
    FILTER/POWDERED AIR-PURIFYING RESPIRATOR; SELF CONTAINED BREATHING
    APPARATUS.
Ventilation:LOCAL MECHANICAL EXHAUST TO MINIMIZE EXPOSURE. BIOLOGICAL
    SAFETY CABINET SHOULD BE USED FOR PREPARATION OF THIS DRUG.
Protective Gloves:SURGICAL LATEX/POLYVINYL CHLORIDE
Eye Protection:CHEMICAL SAFETY GOGGLES
Other Protective Equipment:IMPERVIOUS DISPOSABLE COVERALLS W/CLOSED
    FRONT, LONG SLEEVES & ELASTIC CUFFS & BOOTS TO PROTECT FROM
    DUST/SPLASHES/SPRAY
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING & SHOES
    BEFORE REUSE.
Supplemental Safety and Health
GLOVES SHOULD BE CHANGED REGULARLY & REMOVED IMMEDIATELY AFTER OVERT
    CONTAMINATION. DOUBLE GLOVING IS RECOMMENDED FOR CLEANING. MEDICAL
    SURVEILLANCE RECOMMENDATION: A PRE-PLACEMENT PHYSICAL EXAMINATIO N
    & HISTORY FOR EMPLOYEES W/POTENTIAL EXPOSURE TO PLATINOL IS
    RECOMMENDED. PH: 3.5-5.5 (RECONSTITUTED SOLUTIONS).

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:M.P/F.P Text:518F
pH:(SUPP)
Solubility in Water:1 MG/ML
Appearance and Odor:WHITE LYOPHILIZED POWDER WHICH IS PACKAGED IN VIALS

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
ALUMINUM
Stability Condition to Avoid:REFRIGERATION, LIGHT
Hazardous Decomposition Products:CO, CARBON OXIDES, HYDROGEN CHLORIDE,
    NITROGEN OXIDES

====================  Disposal Considerations  ====================

Waste Disposal Methods:TREAT PRODUCT & CONTAMINATED MATERIALS AS
    HAZARDOUS MATERIAL. INCINERATION IS RECOMMENDED. DISPOSE OF IN
    ACCORDANCE W/LOCAL, STATE & FEDERAL REGULATIONS.

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