p-CRESOL
MSDS Number: C5467 --- Effective Date: 12/08/96
1. Product Identification
Synonyms: 4-methylphenol; 4-Cresol; 1-Hydroxy -4-Methylbenzene
CAS No.: 106-44-5
Molecular Weight: 108.14
Chemical Formula: CH3C6H4OH
Product Codes: F847
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------- ---------
p-Cresol 106-44-5 90 - 100% Yes
3. Hazards Identification
Emergency Overview
--------------------------
DANGER! MAY BE FATAL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN.
CORROSIVE. CAUSES SEVERE BURNS TO EVERY AREA OF CONTACT. AFFECTS CENTRAL
NERVOUS SYSTEM, LIVER, KIDNEYS, PANCREAS AND CARDIOVASCULAR SYSTEM. VAPOR
IS IRRITATING TO EYES AND RESPIRATORY TRACT. COMBUSTIBLE LIQUID AND
VAPOR.
J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience)
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Health Rating: 2 - Moderate
Flammability Rating: 2 - Moderate
Reactivity Rating: 1 - Slight
Contact Rating: 3 - Severe (Corrosive)
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER
GLOVES; CLASS B EXTINGUISHER
Storage Color Code: Red (Flammable)
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Potential Health Effects
----------------------------------
Cresol is toxic via ingestion and skin absorption. Cresol is similar to
phenol in its action on the body, but is less severe in its effects.
Inhalation:
Breathing vapor, dust or mist results in digestive disturbances (vomiting,
difficulty in swallowing, diarrhea, loss of appetite). Will irritate,
possibly burn respiratory tract. Other symptoms listed under ingestion may
also occur.
Ingestion:
Poison. Symptoms may include burning pain in mouth and throat, abdominal
pain, headache, dizziness, muscular weakness, irregular breathing, weak
pulse, lung damage, liver damage, pancreas damage, kidney damage, coma, and
possibly death from circulatory or cardiac failure.
Skin Contact:
Corrosive. Causes severe pain followed by numbness. May be absorbed through
the skin with systemic poisoning effects to follow. Discoloration and
severe burns may occur.
Eye Contact:
Corrosive! Vapors are irritating and may cause damage to the eyes. Contact
may cause severe burns and permanent eye damage.
Chronic Exposure:
Repeated exposure may cause symptoms described for acute poisoning as well
as liver damage.
Aggravation of Pre-existing Conditions:
Persons with pre-existing skin disorders or eye problems or impaired liver
or kidney function may be more susceptible to the effects of the substance.
4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical attention immediately.
Ingestion:
If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never
give anything by mouth to an unconscious person. Get medical attention
immediately.
Skin Contact:
Immediately flush skin with plenty of soap and water for at least 15
minutes while removing contaminated clothing and shoes. Get medical
attention, immediately. Wash clothing before reuse. Thoroughly clean shoes
before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes,
lifting lower and upper eyelids occasionally. Get medical attention
immediately.
Note to Physician:
Onset of systemic effects may be delayed as long as 72 hours.
5. Fire Fighting Measures
Fire:
Flash point: 86C (187F) CC
Autoignition temperature: 559C (1038F)
Flammable limits in air % by volume:
lel: 1.1
Combustible Liquid and Vapor! Contact with strong oxidizers may cause fire.
Explosion:
Above flash point, vapor-air mixtures are explosive within flammable limits
noted above.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in the
pressure demand or other positive pressure mode.
6. Accidental Release Measures
Remove all sources of ignition. Ventilate area of leak or spill. Wear
appropriate personal protective equipment as specified in Section
8.
Solid Spills: Clean up spills in a manner that does not disperse dust into
the air. Use non-sparking tools and equipment. Reduce airborne dust and
prevent scattering by moistening with water. Pick up spill for recovery or
disposal and place in a closed container.
Liquid Spills: Absorb with vermiculite, dry sand, earth or similar
material and place in a chemical waste container. Do not use combustible
materials, such as saw dust. Do not flush to sewer.
Any Spill:
US Regulations (CERCLA) require reporting spills and releases to soil,
water and air in excess of reportable quantities. The toll free number for
the US Coast Guard National Response Center is (800) 424-8802.
J. T. Baker SOLUSORB(tm) solvent adsorbent is recommended for spills of
this product.
7. Handling and Storage
Keep in a tightly closed container. Store in a cool, dry, ventilated area
away from sources of heat or ignition. Protect against physical damage.
Store separately from reactive or combustible materials, and out of direct
sunlight. Containers of this material may be hazardous when empty since
they retain product residues (dust, solids, vapors, liquid); observe all
warnings and precautions listed for the product.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
-OSHA Permissible Exposure Limit (PEL):
5 ppm (TWA) (skin), cresol, all isomers
-ACGIH Threshold Limit Value (TLV):
5 ppm (TWA) (skin), cresol, all isomers
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee
exposures below the Airborne
Exposure Limits. Local exhaust ventilation is generally preferred because
it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH
document, Industrial Ventilation, A Manual of Recommended Practices,
most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, a full facepiece respirator with organic
vapor cartridge and dust/mist filter may be worn up to 50 times the
exposure limit or the maximum use concentration specified by the
appropriate regulatory agency or respirator supplier, whichever is lowest.
For emergencies or instances where the exposure levels are not known, use a
full-facepiece positive-pressure, air-supplied respirator. WARNING: Air
purifying respirators do not protect workers in oxygen-deficient
atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat,
apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or a full face shield where splashing is
possible. Maintain eye wash fountain and quick-drench facilities in work
area.
9. Physical and Chemical Properties
Appearance:
Crystals or liquid becoming dark with age.
Odor:
Phenolic odor.
Solubility:
Slightly soluble in water.
Specific Gravity:
1.0178
pH:
No information found.
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
201C (394F)
Melting Point:
34.8C (95F)
Vapor Density (Air=1):
3.72
Vapor Pressure (mm Hg):
1 @ 53C (127F)
Evaporation Rate (BuAc=1):
No information found.
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
May produce acrid smoke and irritating fumes when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Acids, bases, oxidizing agents.
Conditions to Avoid:
Heat, flames, ignition sources and incompatibles.
11. Toxicological Information
Oral rat LD50: 207 mg/Kg;Inhalation rat LD50: >710 mg/m3; skin rabbit
LD50: 301 mg/kg; investigated as a tumorigen, mutagen.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
p-Cresol (106-44-5) No No None
12. Ecological Information
Environmental Fate:
When released into the soil, this material is expected to readily
biodegrade. When released into the soil, this material is expected to leach
into groundwater. When released into the soil, this material is not
expected to evaporate significantly. When released into water, this
material is expected to readily biodegrade. When released into water, this
material is not expected to evaporate significantly. When released into the
water, this material is expected to have a half-life between 1 and 10 days.
This material has an experimentally-determined bioconcentration factor
(BCF) of less than 100. This material has a log octanol-water partition
coefficient of less than 3.0. This material is not expected to
significantly bioaccumulate. When released into the air, this material is
expected to be readily degraded by reaction with photochemically produced
hydroxyl radicals. When released into the air, this material is expected to
be readily removed from the atmosphere by wet deposition. When released
into the air, this material is expected to have a half-life of less than 1
day.
Environmental Toxicity:
This material is expected to be toxic to aquatic life. The LC50/96-hour
values for fish are between 10 and 100 mg/l.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be handled as
hazardous waste and sent to a RCRA approved waste facility. Processing, use
or contamination of this product may change the waste management options.
State and local disposal regulations may differ from federal disposal
regulations.
Dispose of container and unused contents in accordance with federal, state
and local requirements.
14. Transport Information
Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: CRESOLS
Hazard Class: 6.1, 8
UN/NA: UN2076
Packing Group: II
Information reported for product/size: 500ML
International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: PARA-CRESOLS, SOLID
Hazard Class: 6.1, 8
UN/NA: UN2076
Packing Group: II
Information reported for product/size: 500ML
International (Air, I.C.A.O.)
-----------------------------
Proper Shipping Name: PARA-CRESOLS, SOLID
Hazard Class: 6.1, 8
UN/NA: UN2076
Packing Group: II
Information reported for product/size: 500ML
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
p-Cresol (106-44-5) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
p-Cresol (106-44-5) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
p-Cresol (106-44-5) No No Yes No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
p-Cresol (106-44-5) 100 No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: Yes
SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No
Reactivity: No (Pure / Solid)
Australian Hazchem Code: 2X
Poison Schedule: S6
WHMIS:
This MSDS has been prepared according to the hazard criteria of
the Controlled Products Regulations (CPR) and the MSDS contains
all of the information required by the CPR.
16. Other Information
NFPA Ratings:
Health: 3 Flammability: 1 Reactivity: 0
Label Hazard Warning:
DANGER! MAY BE FATAL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN.
CORROSIVE. CAUSES SEVERE BURNS TO EVERY AREA OF CONTACT. AFFECTS CENTRAL
NERVOUS SYSTEM, LIVER, KIDNEYS, PANCREAS AND CARDIOVASCULAR SYSTEM. VAPOR IS
IRRITATING TO EYES AND RESPIRATORY TRACT. COMBUSTIBLE LIQUID AND VAPOR.
Label Precautions:
Do not breathe vapor.
Do not get in eyes, on skin, or on clothing.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Keep away from heat, sparks and flame.
Label First Aid:
In all cases call a physician immediately. If swallowed, DO NOT INDUCE
VOMITING. Give large quantities of water. Never give anything by mouth to an
unconscious person. If inhaled, remove to fresh air. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. In case of
contact, immediately flush eyes or skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing before
reuse.
Product Use:
Laboratory Reagent.
Revision Information:
Pure. New 16 section MSDS format, all sections have been revised.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good
faith but makes no representation as to its comprehensiveness or accuracy. This
document is intended only as a guide to the appropriate precautionary handling
of the material by a properly trained person using this product. Individuals
receiving the information must exercise their independent judgment in
determining its appropriateness for a particular purpose. MALLINCKRODT BAKER,
INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED,
INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A
PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE
PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC.
WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS
INFORMATION.
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Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)