IMIDAZOLE

MSDS Number: I0080 --- Effective Date: 09/08/97


1. Product Identification

Synonyms: Glyoxaline; Iminazole
CAS No.: 288-32-4
Molecular Weight: 68
Chemical Formula: C3H4N2
Product Codes:
J.T. Baker: N811
Mallinckrodt: 4337

2. Composition/Information on Ingredients


  Ingredient                                CAS No         Percent   Hazardous                                       
  ---------------------------------------   ------------   -------   ---------        
 
  Imidazole                                 288-32-4       90 - 100%    Yes                                                                  
 

3. Hazards Identification

Emergency Overview
--------------------------
WARNING! CAUSES IRRITATION TO EYES AND SKIN. MAY BE HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN.

J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience)
-----------------------------------------------------------------------------------------------------------
Health Rating: 2 - Moderate
Flammability Rating: 1 - Slight
Reactivity Rating: 1 - Slight
Contact Rating: 3 - Severe (Corrosive)
Lab Protective Equip: GOGGLES; LAB COAT
Storage Color Code: White (Corrosive)
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Potential Health Effects
----------------------------------

Information on the human health effects from exposure to this substance is limited.

Inhalation:
May cause irritation to the respiratory tract. Symptoms may include coughing and shortness of breath.
Ingestion:
Large oral doses may cause irritation to the gastrointestinal tract.
Skin Contact:
Causes irritation to skin. Symptoms include redness, itching, and pain. May be absorbed through the skin with possible systemic effects.
Eye Contact:
Causes irritation, redness, and pain.
Chronic Exposure:
No information found.
Aggravation of Pre-existing Conditions:
No information found.

4. First Aid Measures

Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion:
Give large amounts of water to drink. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

5. Fire Fighting Measures

Fire:
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.

6. Accidental Release Measures

Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery or disposal and place in a closed container.


7. Handling and Storage

Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product. Isolate from incompatible substances.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
- OSHA Permissible Exposure Limit (PEL):
15 mg/m3 total dust, 5 mg/m3 respirable fraction for nuisance dusts.
- ACGIH Threshold Limit Value (TLV):
10 mg/m3 total dust containing no asbestos and < 1% crystalline silica for Particulates Not Otherwise Classified (PNOC).
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, a half-face dust/mist respirator may be worn for up to ten times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. A full-face piece dust/mist respirator may be worn up to 50 times the exposure limit, or the maximum use concentration specified by the appropriate regulatory agency, or respirator supplier, whichever is lowest. For emergencies or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area.

9. Physical and Chemical Properties

Appearance:
White flakes.
Odor:
No information found.
Solubility:
Soluble in water.
Specific Gravity:
0.60
pH:
No information found.
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
256C (493F)
Melting Point:
89 - 91C (192 - 196F)
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.

10. Stability and Reactivity

Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides.
Hazardous Polymerization:
This substance does not polymerize.
Incompatibilities:
Strong oxidizers.
Conditions to Avoid:
No information found.

11. Toxicological Information


Oral rat LD50: 220 mg/Kg. Investigated as a mutagen, reproductive effector.
  --------\Cancer Lists\------------------------------------------------------
                                         ---NTP Carcinogen---
  Ingredient                             Known    Anticipated    IARC Category
  ------------------------------------   -----    -----------    -------------
  Imidazole (288-32-4)                    No          No            None

12. Ecological Information

Environmental Fate:
No information found.
Environmental Toxicity:
No information found.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

14. Transport Information

Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: CORROSIVE SOLID, BASIC, ORGANIC, N.O.S. (IMIDAZOLE)
Hazard Class: 8
UN/NA: UN3263
Packing Group: III
Information reported for product/size: 5KG

International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: CORROSIVE SOLID, BASIC, ORGANIC, N.O.S. (IMIDAZOLE)
Hazard Class: 8
UN/NA: UN3263
Packing Group: III
Information reported for product/size: 5KG


15. Regulatory Information

  --------\Chemical Inventory Status - Part 1\---------------------------------
  Ingredient                                       TSCA  EC   Japan  Australia
  -----------------------------------------------  ----  ---  -----  ---------
  Imidazole (288-32-4)                              Yes  Yes   Yes      Yes                                      
 
  --------\Chemical Inventory Status - Part 2\---------------------------------
                                                          --Canada--
  Ingredient                                       Korea  DSL   NDSL  Phil.
  -----------------------------------------------  -----  ---   ----  -----
  Imidazole (288-32-4)                              Yes   Yes   No     Yes                             
 
  --------\Federal, State & International Regulations - Part 1\----------------
                                             -SARA 302-    ------SARA 313------
  Ingredient                                 RQ    TPQ     List  Chemical Catg.
  -----------------------------------------  ---   -----   ----  --------------
  Imidazole (288-32-4)                       No    No      No         No
 
  --------\Federal, State & International Regulations - Part 2\----------------
                                                        -RCRA-    -TSCA-
  Ingredient                                 CERCLA     261.33     8(d) 
  -----------------------------------------  ------     ------    ------
  Imidazole (288-32-4)                       No         No         No                   
 
 
Chemical Weapons Convention:  No     TSCA 12(b):  No     CDTA:  No
SARA 311/312:  Acute: Yes      Chronic: No   Fire: No  Pressure: No
Reactivity: No          (Pure / Solid) 


Australian Hazchem Code: No information found.
Poison Schedule: No information found.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.

16. Other Information

NFPA Ratings: Health: 1 Flammability: 1 Reactivity: 0
Label Hazard Warning:
WARNING! CAUSES IRRITATION TO EYES AND SKIN. MAY BE HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN.
Label Precautions:
Avoid contact with eyes, skin and clothing.
Wash thoroughly after handling.
Avoid breathing dust.
Use with adequate ventilation.
Keep container closed.
Label First Aid:
In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. If swallowed, give large amounts of water to drink. Never give anything by mouth to an unconscious person. In all cases, get medical attention.
Product Use:
Laboratory Reagent.
Revision Information:

Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)