MALEIC ANHYDRIDE

MSDS Number: M0364 --- Effective Date: 02/16/98


1. Product Identification

Synonyms: cis-Butenedioic anhydride; 2,5-furandione; toxilic anhydride
CAS No.: 108-31-6
Molecular Weight: 98.06
Chemical Formula: C4H2O3
Product Codes:
J.T. Baker: P469
Mallinckrodt: 1901

2. Composition/Information on Ingredients


  Ingredient                                CAS No         Percent   Hazardous                                       
  ---------------------------------------   ------------   -------   ---------        
 
  Maleic Anhydride                          108-31-6         100%       Yes                                                               
 

3. Hazards Identification

Emergency Overview
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DANGER! CORROSIVE. CAUSES BURNS TO SKIN AND EYES. MAY CAUSE IRRITATION AND/OR ALLERGIC REACTION IN THE RESPIRATORY TRACT. MELTED MATERIAL CAUSES THERMAL BURNS. MAY BE HARMFUL IF SWALLOWED.

J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience)
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Health Rating: 3 - Severe (Life)
Flammability Rating: 1 - Slight
Reactivity Rating: 2 - Moderate
Contact Rating: 3 - Severe (Corrosive)
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color Code: White (Corrosive)
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Potential Health Effects
----------------------------------

Inhalation:
Inhalation of dust or vapor may cause irritation of the nose and throat. Coughing, sneezing, and burning of the throat may be experienced. Can cause allergic respiratory reactions.
Ingestion:
Corrosive. Toxic. Swallowing can cause sore throat, abdominal pain, and vomiting. May cause burns to the digestive tract.
Skin Contact:
Corrosive. May not cause immediate burning of the skin, but prolonged contact with moist skin cause reddening and blistering or burns.
Eye Contact:
Corrosive. Dust or vapor cause burns or irritation of the eyes with swelling. Sensitivity to light and double vision may occur.
Chronic Exposure:
Repeated inhalation may cause chronic bronchitis of the asthmatic type. Repeated skin contact may lead to dermatitis or sensitization.
Aggravation of Pre-existing Conditions:
No information found.

4. First Aid Measures

Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact:
In case of contact, immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Call a physician immediately.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

5. Fire Fighting Measures

Fire:
Flash point: 102C (216F) CC
Autoignition temperature: 477C (891F)
Flammable limits in air % by volume:
lel: 1.4; uel: 7.1
Explosion:
Above flash point, vapor-air mixtures are explosive within flammable limits noted above.
Fire Extinguishing Media:
Alcohol foam, carbon dioxide. DO NOT USE dry chemical, multipurpose dry chemical, or loaded stream media because of explosion potential due to reactivity of basic compounds in these extinguishing media.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.

6. Accidental Release Measures

Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery or disposal and place in a closed container. Evacuate area of all unnecessary personnel. US Regulations (CERCLA) require reporting spills and releases to soil, water and air in excess of reportable quantities. The toll free number for the US Coast Guard National Response Center is (800) 424-8802.


7. Handling and Storage

Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Isolate from incompatible substances. Do not reuse container. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product. Avoid dust formation and control ignition sources. Employ grounding, venting and explosion relief provisions in accord with accepted engineering practices in any process capable of generating dust and/or static electricity. Empty only into inert or non-flammable atmosphere. Emptying contents into a non-inert atmosphere where flammable vapors may be present could cause a flash fire or explosion due to electrostatic discharge.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
-OSHA Permissible Exposure Limit (PEL): 0.25 ppm, 1 mg/m3 (TWA)

-ACGIH Threshold Limit Value (TLV): 0.25 ppm,1 mg/m3 (TWA)
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, a full facepiece respirator with organic vapor cartridge and dust/mist filter may be worn up to 50 times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. For emergencies or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.

9. Physical and Chemical Properties

Appearance:
White crystals.
Odor:
Sharp irritating acrid odor.
Solubility:
16.3 g/100ml water @ 25C (77F); slowly hydrolyzes.
Specific Gravity:
1.48
pH:
No information found.
% Volatiles by volume @ 21C (70F):
No information found.
Boiling Point:
202C (396F)
Melting Point:
53C (127F)
Vapor Density (Air=1):
3.38
Vapor Pressure (mm Hg):
0.16 @ 20C (68F)
Evaporation Rate (BuAc=1):
No information found.

10. Stability and Reactivity

Stability:
Stable under ordinary conditions of use and storage. Readily sublimes. Decomposes slowly with water forming maleic acid. When dissolved in water it is a strong acid. Molten product should be stored under 70C (158F)
Hazardous Decomposition Products:
Carbon dioxide and carbon monoxide may form when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Incompatible with alkali metals, alkaline earth metals, amines > 66C (150F). Reacts violently with bases. Contact with strong oxidizers may cause fires and explosions.
Conditions to Avoid:
Moisture, heat, flames, ignition sources and incompatibles.

11. Toxicological Information


Oral rat LD50: 400 mg/Kg; Skin rabbit LD50: 2620 mg/Kg Standard Draize rabbit,eye,1%, severe Investigated as a tumorigen, mutagen, reproductive effector.
  --------\Cancer Lists\------------------------------------------------------
                                         ---NTP Carcinogen---
  Ingredient                             Known    Anticipated    IARC Category
  ------------------------------------   -----    -----------    -------------
  Maleic Anhydride (108-31-6)             No          No            None

12. Ecological Information

Environmental Fate:
When released to air, soil and water; maleic anhydride will probably hydrolyze to maleic acid and be processed as follows. When released into the soil, this material is expected to leach into groundwater. When released into the soil, this material is expected to readily biodegrade. When released into water, this material is expected to readily biodegrade. When released into water, this material is not expected to evaporate significantly. When released into the air, this material is expected to exist in the aerosol phase with a short half-life. When released into the air, this material is not expected to be subject to wet deposition. When released into the air, this material is expected to be degraded by reaction with ozone and photochemically produced hydroxyl radicals. This material is not expected to significantly bioaccumulate. This material has an estimated bioconcentration factor (BCF) of less than 100.
Environmental Toxicity:
When released to soil and water; maleic anhydride will probably hydrolyze to maleic acid and be represented by the following data for maleic acid.
TLm /Fathead minnow/5ppm/96 hr./fresh water
TLm/Mosquito fish/240 ppm/24-48 hr./fresh water

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to a RCRA approved incinerator or disposed in a RCRA approved waste facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

14. Transport Information

Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: MALEIC ANHYDRIDE
Hazard Class: 8
UN/NA: UN2215
Packing Group: III
Information reported for product/size: 500G

International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: MALEIC ANHYDRIDE
Hazard Class: 8
UN/NA: UN2215
Packing Group: III
Information reported for product/size: 500G


15. Regulatory Information

  --------\Chemical Inventory Status - Part 1\---------------------------------
  Ingredient                                       TSCA  EC   Japan  Australia
  -----------------------------------------------  ----  ---  -----  ---------
  Maleic Anhydride (108-31-6)                       Yes  Yes   Yes      Yes                                      
 
  --------\Chemical Inventory Status - Part 2\---------------------------------
                                                          --Canada--
  Ingredient                                       Korea  DSL   NDSL  Phil.
  -----------------------------------------------  -----  ---   ----  -----
  Maleic Anhydride (108-31-6)                       Yes   Yes   No     Yes                             
 
  --------\Federal, State & International Regulations - Part 1\----------------
                                             -SARA 302-    ------SARA 313------
  Ingredient                                 RQ    TPQ     List  Chemical Catg.
  -----------------------------------------  ---   -----   ----  --------------
  Maleic Anhydride (108-31-6)                No    No      Yes        No
 
  --------\Federal, State & International Regulations - Part 2\----------------
                                                        -RCRA-    -TSCA-
  Ingredient                                 CERCLA     261.33     8(d) 
  -----------------------------------------  ------     ------    ------
  Maleic Anhydride (108-31-6)                5000       U147       No                   
 
 
Chemical Weapons Convention:  No     TSCA 12(b):  No     CDTA:  No
SARA 311/312:  Acute: Yes      Chronic: Yes  Fire: No  Pressure: No
Reactivity: Yes         (Pure / Solid)  


Australian Hazchem Code: 2X
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.

16. Other Information

NFPA Ratings: Health: 3 Flammability: 1 Reactivity: 1
Label Hazard Warning:
DANGER! CORROSIVE. CAUSES BURNS TO SKIN AND EYES. MAY CAUSE IRRITATION AND/OR ALLERGIC REACTION IN THE RESPIRATORY TRACT. MELTED MATERIAL CAUSES THERMAL BURNS. MAY BE HARMFUL IF SWALLOWED.
Label Precautions:
Do not breathe dust or vapor.
Do not get in eyes, on skin, or on clothing.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Keep away from heat, sparks and flame.
Label First Aid:
In all cases call a physician immediately. If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of skin contact, immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.Thoroughly clean shoes before reuse. In case of eye contact, immediately flush eyes with plenty of water for at least 15 minutes. In all cases call a physician immediately..
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last revision of document include: 14, 15.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)