2-METHOXYETHANOL
MSDS Number: M2327 --- Effective Date: 12/08/96
1. Product Identification
Synonyms: Ethylene glycol monoethyl ether; methyl cellosolve(tm);
methoxyhydroxyethane
CAS No.: 109-86-4
Molecular Weight: 76.09
Chemical Formula: CH3OC2H4OH
Product Codes: J.T. Baker:
P784
Mallinckrodt:
2683
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------- ---------
2-Methoxyethanol 109-86-4 100% Yes
3. Hazards Identification
Emergency Overview
--------------------------
WARNING! FLAMMABLE LIQUID AND VAPOR. MAY FORM EXPLOSIVE PEROXIDES IN
AIR. HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. AFFECTS
CENTRAL NERVOUS SYSTEM, BLOOD AND BLOOD FORMING ORGANS, REPRODUCTIVE SYSTEM
AND KIDNEYS. POSSIBLE BIRTH DEFECT HAZARD. MAY CAUSE BIRTH DEFECTS BASED ON
ANIMAL DATA. MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT.
J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience)
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Health Rating: 3 - Severe (Life)
Flammability Rating: 2 - Moderate
Reactivity Rating: 2 - Moderate
Contact Rating: 3 - Severe (Life)
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER
GLOVES; CLASS B EXTINGUISHER
Storage Color Code: Red (Flammable)
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Potential Health Effects
----------------------------------
Inhalation:
Inhalation of vapors may cause irritation, headache, dizziness, fatigue,
nausea, vomiting, and loss of appetite. Weakness, incoordination and
tremors may occur.
Ingestion:
Moderately toxic. Can cause headache, fatigue, nausea, vomiting, dizziness,
and weakness. Hemorrhagic gastritis, liver damage, pancreas damage and
brain edema resulting in death has occurred in human exposure of 3 g/kg.
Damage to kidneys is possible from ingestion of large quantities.
Skin Contact:
May cause irritation with redness and pain. May be absorbed through the
skin with possible systemic effects.
Eye Contact:
May cause irritation, redness and pain.
Chronic Exposure:
Prolonged exposure may cause injury to bone marrow, blood cells, kidney,
liver and testes. A suspected human reproductive hazard and a birth defect
hazard. Severe neurological disabilities has been reported from chronic
industrial exposure. Symptoms have included headache, dizziness, lethargy,
weakness, personality changes, apathy, unequal pupil size, and
disorientation.
Aggravation of Pre-existing Conditions:
Persons with pre-existing blood or central nervous system disorders may be
more susceptible to the effects of this substance.
4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Call a physician.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give
anything by mouth to an unconscious person. Call a physician.
Skin Contact:
Immediately flush skin with plenty of soap and water for at least 15
minutes while removing contaminated clothing and shoes. Get medical
attention. Wash clothing before reuse. Thoroughly clean shoes before
reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes,
lifting lower and upper eyelids occasionally. Get medical attention
immediately.
5. Fire Fighting Measures
Fire:
Flash point: 39C (102F)
Autoignition temperature: 286C (547F)
Flammable limits in air % by volume:
lel: 1.8; uel: 14
Flammable.
Explosion:
Above flash point, vapor-air mixtures are explosive within flammable limits
noted above. Contact with strong oxidizers may cause fire. Vapors can flow
along surfaces to distant ignition source and flash back. Sensitive to
static discharge.
Fire Extinguishing Media:
Dry chemical, foam or carbon dioxide. Water spray may be used to keep fire
exposed containers cool, dilute spills to nonflammable mixtures, protect
personnel attempting to stop leak and disperse vapors.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in the
pressure demand or other positive pressure mode.
6. Accidental Release Measures
Ventilate area of leak or spill. Remove all sources of ignition. Wear
appropriate personal protective equipment as specified in Section 8.
Isolate hazard area. Keep unnecessary and unprotected personnel from
entering. Contain and recover liquid when possible. Use non-sparking tools
and equipment. Collect liquid in an appropriate container or absorb with an
inert material (e. g., vermiculite, dry sand, earth), and place in a
chemical waste container. Do not use combustible materials, such as saw
dust. Do not flush to sewer! If a leak or spill has not ignited, use water
spray to disperse the vapors, to protect personnel attempting to stop leak,
and to flush spills away from exposures.
J. T. Baker SOLUSORB(tm) solvent adsorbent is recommended for spills of
this product.
7. Handling and Storage
Protect against physical damage. Store in a cool, dry well-ventilated
location, away from any area where the fire hazard may be acute. Outside or
detached storage is preferred. Separate from incompatibles. Containers
should be bonded and grounded for transfers to avoid static sparks. Storage
and use areas should be No Smoking areas. Use non-sparking type tools and
equipment, including explosion proof ventilation. Be aware of possible
peroxide formation. Avoid use of aluminum and magnesium equipment.
Containers of this material may be hazardous when empty since they retain
product residues (vapors, liquid); observe all warnings and precautions
listed for the product. Sudden release of hot organic chemical vapors or
mists from process equipment operating at elevated temperatures and
pressure, or sudden ingress of air into vacuum equipment, may result in
ignitions without the presence of ignition sources. Published
"autoignition" or "ignition" temperature values cannot be treated as safe
operating temperatures in chemical processes without analysis of the actual
process conditions.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
2-Methoxyethanol (EGME):
-OSHA Permissible Exposure Limit (PEL):
25 ppm (TWA) skin, Methyl Cellosolve
-ACGIH Threshold Limit Value (TLV):
5 ppm (TWA) skin
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee
exposures below the Airborne
Exposure Limits. Local exhaust ventilation is generally preferred because
it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH
document, Industrial Ventilation, A Manual of Recommended Practices,
most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded, a half-face organic vapor respirator may
be worn for up to ten times the exposure limit or the maximum use
concentration specified by the appropriate regulatory agency or respirator
supplier, whichever is lowest. A full-face piece organic vapor respirator
may be worn up to 50 times the exposure limit or the maximum use
concentration specified by the appropriate regulatory agency or respirator
supplier, whichever is lowest. For emergencies or instances where the
exposure levels are not known, use a full-face piece positive-pressure,
air-supplied respirator. WARNING: Air-purifying respirators do not protect
workers in oxygen-deficient atmospheres.
Skin Protection:
Rubber or neoprene gloves and additional protection including impervious
boots, apron, or coveralls, as needed in areas of unusual exposure.
Eye Protection:
Use chemical safety goggles. Maintain eye wash fountain and quick-drench
facilities in work area.
9. Physical and Chemical Properties
Appearance:
Clear, colorless liquid.
Odor:
Pleasant odor.
Solubility:
Miscible in water.
Specific Gravity:
0.96 @ 20C/4C
pH:
No information found.
% Volatiles by volume @ 21C (70F):
100
Boiling Point:
124C (255F)
Melting Point:
-85.1C (-121F)
Vapor Density (Air=1):
2.62
Vapor Pressure (mm Hg):
6.2 @ 20C (68F)
Evaporation Rate (BuAc=1):
ca. 1
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage. Formation of explosive
peroxides has been reported from auto-oxidation. Reported to dissolve
aluminum from scratched or heated aluminum surfaces. Do not distill to
dryness. Avoid excessive temperatures or prolonged reflux, such as in batch
distillations.
Hazardous Decomposition Products:
Carbon dioxide and carbon monoxide may form when heated to decomposition.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizers and alkalis, strong acids, high temperatures in the
presence of strong bases. Contact with excessive heat, open flame, sparks,
or ignition sources.
Conditions to Avoid:
Heat, flame, ignition sources, air, incompatibles
11. Toxicological Information
Toxicological Data:
Oral rat LD50: 2370 mg/kg; inhalation rat LC50: 1500 ppm/7H; skin rabbit
LD50: 1280 mg/kg.
Reproductive Toxicity:
In laboratory animals, this compound has caused both birth defects and
damage to the reproductive system.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
2-Methoxyethanol (109-86-4) No No None
12. Ecological Information
Environmental Fate:
When released into the soil, this material may leach into groundwater. When
released into the soil, this material may evaporate to a moderate extent.
When released into water, this material may biodegrade to a moderate
extent. This material has a log octanol-water partition coefficient of less
than 3.0. This material is not expected to significantly bioaccumulate.
When released into the air, this material is expected to be readily
degraded by reaction with photochemically produced hydroxyl radicals. When
released into the air, this material is expected to have a half-life of
less than 1 day. When released into the air, this material may be removed
from the atmosphere to a moderate extent by wet deposition.
Environmental Toxicity:
The LC50/96-hour values for fish are over 100 mg/l. This material is not
expected to be toxic to aquatic life.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be handled as
hazardous waste and sent to a RCRA approved incinerator or disposed in a
RCRA approved waste facility. Processing, use or contamination of this
product may change the waste management options. State and local disposal
regulations may differ from federal disposal regulations.
Dispose of container and unused contents in accordance with federal, state
and local requirements.
14. Transport Information
Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: ETHYLENE GLYCOL MONOMETHYL ETHER
Hazard Class: 3
UN/NA: UN1188
Packing Group: III
Information reported for product/size: 4L
International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: ETHYLENE GLYCOL MONOMETHYL ETHER
Hazard Class: 3.3
UN/NA: UN1188
Packing Group: III
Information reported for product/size: 4L
International (Air, I.C.A.O.)
-----------------------------
Proper Shipping Name: ETHYLENE GLYCOL MONOMETHYL ETHER
Hazard Class: 3.3
UN/NA: UN1188
Packing Group: III
Information reported for product/size: 4L
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
2-Methoxyethanol (109-86-4) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
2-Methoxyethanol (109-86-4) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
2-Methoxyethanol (109-86-4) No No Yes No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
2-Methoxyethanol (109-86-4) No No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No
Reactivity: Yes (Pure / Liquid)
Prop 65:
THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE STATE OF
CALIFORNIA TO CAUSE BIRTH DEFECTS OR OTHER REPRODUCTIVE HARM.
Australian Hazchem Code: 2[S]
Poison Schedule: No information found.
WHMIS:
This MSDS has been prepared according to the hazard criteria of
the Controlled Products Regulations (CPR) and the MSDS contains
all of the information required by the CPR.
16. Other Information
NFPA Ratings:
Health: 2 Flammability: 2 Reactivity: 2
Label Hazard Warning:
WARNING! FLAMMABLE LIQUID AND VAPOR. MAY FORM EXPLOSIVE PEROXIDES IN AIR.
HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. AFFECTS CENTRAL
NERVOUS SYSTEM, BLOOD AND BLOOD FORMING ORGANS, REPRODUCTIVE SYSTEM AND
KIDNEYS. POSSIBLE BIRTH DEFECT HAZARD. MAY CAUSE BIRTH DEFECTS BASED ON
ANIMAL DATA. MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT.
Label Precautions:
Avoid breathing vapor or mist.
Avoid contact with eyes, skin and clothing.
Keep away from heat, sparks and flame.
Keep container closed.
Wash thoroughly after handling.
Use only with adequate ventilation.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel.
Never give anything by mouth to an unconscious person. If inhaled, remove to
fresh air. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. In case of contact, immediately flush eyes or skin
with plenty of water for at least 15 minutes while removing contaminated
clothing and shoes. Wash clothing before reuse. In all cases call a
physician.
Product Use:
Laboratory Reagent.
Revision Information:
Pure. New 16 section MSDS format, all sections have been revised.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good
faith but makes no representation as to its comprehensiveness or accuracy. This
document is intended only as a guide to the appropriate precautionary handling
of the material by a properly trained person using this product. Individuals
receiving the information must exercise their independent judgment in
determining its appropriateness for a particular purpose. MALLINCKRODT BAKER,
INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED,
INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A
PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE
PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC.
WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS
INFORMATION.
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Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)