p-Nitroaniline

MSDS Number: N4170 --- Effective Date: 12/08/96


1. Product Identification

Synonyms: p-Aminonitrobenzene;PNA;4-Nitroaniline
CAS No.: 100-01-6
Molecular Weight: 138.13
Chemical Formula: NO2C6H4NH2
Product Codes: R871


2. Composition/Information on Ingredients


  Ingredient                                CAS No         Percent   Hazardous                                       
  ---------------------------------------   ------------   -------   ---------        
 
  p-Nitroaniline                            100-01-6       95 - 100%    Yes                                                                  
 


3. Hazards Identification

Emergency Overview
--------------------------
POISON! DANGER! HAZARDOUS SOLID AND DUST. HIGHLY TOXIC. RAPIDLY ABSORBED THROUGH SKIN. CAUSES METHEMOGLOBINEMIA, DECREASING OXYGEN IN BLOOD. COMBUSTIBLE DUST - EXPLOSION POTENTIAL. MAY BE FATAL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN. HANDLE IN A FUME HOOD. TARGET ORGAN(S): Lungs, heart, blood, liver.


J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience)
-----------------------------------------------------------------------------------------------------------
Health Rating: 3 - Severe (Life)
Flammability Rating: 1 - Slight
Reactivity Rating: 1 - Slight
Contact Rating: 3 - Severe (Life)
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color Code: Blue (Health)
-----------------------------------------------------------------------------------------------------------

Potential Health Effects
----------------------------------

EFFECTS OF EXPOSURE Inhalation and skin contact are expected to be the primary routes of occupational exposure to para-Nitroaniline. para-Nitroaniline is readily absorbed through human skin. Although para-Nitroaniline is considered to be only slightly toxic on the basis of single exposure animal tests, human experience has shown that man is much more sensitive to methemoglobinemia caused by aromatic amino compounds than the rat or the rabbit.Methemoglobinemia is a condition caused by changes in the blood cells which decrease the oxygen-carrying capacity of the blood. Cyanosis may occur and, as oxygen deficiency increases,there may be associated headache, weakness, irritability, drowsiness, shortness of breath, and unconsciousness. The appearance of methemoglobinemia may be delayed 0 to 12 hours after exposure. Because of the high potential for this material to cause methemoglobin formation, para-nitroaniline should be considered HAZARDOUS by all routes of exposure and exposures should be tightly controlled.

Inhalation:
Headache, coughing, dizziness, difficult breathing, nausea, vomiting, increased heart rate, cyanosis, unconsciousness.

Ingestion:
Nausea, vomiting, increased heart rate, methemoglobinemia cyanosis, (bluish discoloration of skin)

Skin Contact:
Not a skin irritant May be absorbed through the skin with possible systemic effects.

Eye Contact:
Slight irritation, with discomfort, tearing, blurring of vision.

Chronic Exposure:
Liver damage, kidney damage, bone marrow, blood damage.

Aggravation of Pre-existing Conditions:
Liver disorders.


4. First Aid Measures

Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Prompt action is essential.

Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention.

Skin Contact:
Immediately remove contaminated clothing and wash affected area thoroughly with soap and water.

Eye Contact:
In case of eye contact, immediately flush with plenty of water for at least 15 minutes.

Note to Physician:
Absorption of this product into the body may lead to the formation of methemoglobin that, in sufficient concentration, causes cyanosis. Since reversion of methemoglobin to hemoglobin occurs spontaneously after termination of exposure, moderate degrees of cyanosis need be treated only by supportive measures such as bed rest and oxygen inhalation. Thorough cleansing of the entire contaminated area of the body, including scalp and nails, is of utmost importance. If cyanosis is severe, intravenous injection of methylene blue, one milligram per kilogram of body weight, may be of value. Cyanocobalamin (Vitamin B12), one milligram intramuscularly, may speed recovery. Intravenous fluids and bloodtransfusions may be indicated in very severe exposure.


5. Fire Fighting Measures

Fire:
Flash point: 199C (390F) CC

Explosion:
Combustible dust. This material, like most organic materials in powder form, is capable of creating a dust explosion. Refer to NFPA pamphlet No. 654. "Standard for the Prevention of Fire and Dust Explosions in the Chemical, Dye, Pharmaceutical and Plastics Industries" if the material is to be reduced to or collected as a powder. Sensitive to static discharge.

Fire Extinguishing Media:
Water, dry chemical, foam or carbon dioxide.

Special Information:
Firefighters should wear proper protective equipment and self-contained breathing apparatus with full facepiece operated in positive pressure mode. Fire fighting equipment should be thoroughly decontaminated after use. This material, as normally packaged and handled, can contain sufficient fines to present a potential dust explosion hazard if a sufficient quantity of this material is dispersed in air.


6. Accidental Release Measures

Wear self-contained breathing apparatus and full protective clothing. With clean shovel, carefully place material into clean, dry container and cover; remove from area. Flush spill area with water. Ventilate area.


7. Handling and Storage

Store in a cool place away from heated areas, sparks, and flame. Store in a well ventilated area. Store away from incompatible materials. Keep containers tightly closed and dry. Avoid contact with skin and eyes. Avoid dust formation Protect from freezing. Use only in a chemical fume hood. Do not breathe dust. Do not get in eyes, on skin, or on clothing. Avoid prolonged or repeated exposure. Wash thoroughly after handling. Keep it dry. Moisture causes nitration of organic materials and may result in spontaneous ignition. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.


8. Exposure Controls/Personal Protection

Airborne Exposure Limits:
-OSHA Permissible Exposure Limit (PEL): 1 ppm (TWA) The PEL listed denotes PEL (skin). -ACGIH Threshold Limit Value (TLV): 3 mg/m3 (TWA) The TLV listed denotes TLV (skin).

Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.

Personal Respirators (NIOSH Approved):
For conditions of use where exposure to the substance is apparent, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.

Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.

Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.


9. Physical and Chemical Properties

Appearance:
Yellow Powder.

Odor:
Faint amine odor.

Solubility:
Negligible (<0.1%)

Specific Gravity:
1.44

pH:
No information found.

% Volatiles by volume @ 21C (70F):
0

Boiling Point:
332C (630F)

Melting Point:
149C (300F)

Vapor Density (Air=1):
4.77

Vapor Pressure (mm Hg):
Not applicable.

Evaporation Rate (BuAc=1):
No information found.


10. Stability and Reactivity

Stability:
Stable under ordinary conditions of use and storage.

Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, oxides of nitrogen.

Hazardous Polymerization:
Will not occur.

Incompatibilities:
Strong oxidizing agents, strong acids, strong reducing agents, strong bases, alcohols, ketones, aldehydes.

Conditions to Avoid:
Heat, flame, other sources of ignition, moisture.


11. Toxicological Information

Reproductive Toxicity:
The compound does produce genetic damage in bacterial cell cultures but does not produce genetic damage in animals. It does not produce heritable genetic damage.

  --------\Cancer Lists\------------------------------------------------------
                                         ---NTP Carcinogen---
  Ingredient                             Known    Anticipated    IARC Category
  ------------------------------------   -----    -----------    -------------
  p-Nitroaniline (100-01-6)               No          No            None


12. Ecological Information

Environmental Fate:
No information found.

Environmental Toxicity:
Daphnia Magna: 48 Hr-LC50 = 20-30 ppm, slightly toxic. Rainbow Trout: 96 Hr-LC50 = 45 ppm, slightly toxic. Bluegill Sunfish: 96 Hr-LC50 = 80 ppm, slightly toxic.


13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to a RCRA approved waste facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.


14. Transport Information

Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: NITROANILINES
Hazard Class: 6.1
UN/NA: UN1661
Packing Group: II
Information reported for product/size: 100G

International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: NITROANILINES
Hazard Class: 6.1
UN/NA: UN1661
Packing Group: II
Information reported for product/size: 100G

International (Air, I.C.A.O.)
-----------------------------
Proper Shipping Name: NITROANILINES
Hazard Class: 6.1
UN/NA: UN1661
Packing Group: II
Information reported for product/size: 100G



15. Regulatory Information


  --------\Chemical Inventory Status - Part 1\---------------------------------
  Ingredient                                       TSCA  EC   Japan  Australia
  -----------------------------------------------  ----  ---  -----  ---------
  p-Nitroaniline (100-01-6)                         Yes  Yes   Yes      Yes                                      
 
  --------\Chemical Inventory Status - Part 2\---------------------------------
                                                          --Canada--
  Ingredient                                       Korea  DSL   NDSL  Phil.
  -----------------------------------------------  -----  ---   ----  -----
  p-Nitroaniline (100-01-6)                         Yes   Yes   No     Yes                             
 
  --------\Federal, State & International Regulations - Part 1\----------------
                                             -SARA 302-    ------SARA 313------
  Ingredient                                 RQ    TPQ     List  Chemical Catg.
  -----------------------------------------  ---   -----   ----  --------------
  p-Nitroaniline (100-01-6)                  No    No      Yes        No
 
  --------\Federal, State & International Regulations - Part 2\----------------
                                                        -RCRA-    -TSCA-
  Ingredient                                 CERCLA     261.33     8(d) 
  -----------------------------------------  ------     ------    ------
  p-Nitroaniline (100-01-6)                  5000       P077       Yes                  
 
 
Chemical Weapons Convention:  No     TSCA 12(b):  No     CDTA:  No
SARA 311/312:  Acute: Yes      Chronic: Yes  Fire: No  Pressure: No
Reactivity: Yes         (Pure / Solid)  


Australian Hazchem Code: 2X
Poison Schedule: No information found.

WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.


16. Other Information

NFPA Ratings: Health: 3 Flammability: 1 Reactivity: 3

Label Hazard Warning:
POISON! DANGER! HAZARDOUS SOLID AND DUST. HIGHLY TOXIC. RAPIDLY ABSORBED THROUGH SKIN. CAUSES METHEMOGLOBINEMIA, DECREASING OXYGEN IN BLOOD. COMBUSTIBLE DUST - EXPLOSION POTENTIAL. MAY BE FATAL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN. HANDLE IN A FUME HOOD. TARGET ORGAN(S): Lungs, heart, blood, liver.

Label Precautions:
Do not get in eyes, on skin, on clothing. Do not breathe dust. Keep in tightly closed container. Use with adequate ventilation. Wash thoroughly after handling. In case of fire, soak with water. In case of spill, sweep up and remove. Flush spill area with water.

Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Prompt action is essential. In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Product Use:
Laboratory Reagent.

Revision Information:
Pure. New 16 section MSDS format, all sections have been revised.

Disclaimer:
************************************************************************************************ Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
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Phone Number: (314) 539-1600 (U.S.A.)