p-Nitroaniline
MSDS Number: N4170 --- Effective Date: 12/08/96
1. Product Identification
Synonyms: p-Aminonitrobenzene;PNA;4-Nitroaniline
CAS No.: 100-01-6
Molecular Weight: 138.13
Chemical Formula: NO2C6H4NH2
Product Codes: R871
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------- ---------
p-Nitroaniline 100-01-6 95 - 100% Yes
3. Hazards Identification
Emergency Overview
--------------------------
POISON! DANGER! HAZARDOUS SOLID AND DUST. HIGHLY TOXIC. RAPIDLY
ABSORBED THROUGH SKIN. CAUSES METHEMOGLOBINEMIA, DECREASING OXYGEN IN
BLOOD. COMBUSTIBLE DUST - EXPLOSION POTENTIAL. MAY BE FATAL IF SWALLOWED,
INHALED, OR ABSORBED THROUGH SKIN. HANDLE IN A FUME HOOD.
TARGET ORGAN(S): Lungs, heart, blood, liver.
J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for your convenience)
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Health Rating: 3 - Severe (Life)
Flammability Rating: 1 - Slight
Reactivity Rating: 1 - Slight
Contact Rating: 3 - Severe (Life)
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color Code: Blue (Health)
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Potential Health Effects
----------------------------------
EFFECTS OF EXPOSURE Inhalation and skin contact are expected to be the
primary routes of occupational exposure to para-Nitroaniline.
para-Nitroaniline is readily absorbed through human skin. Although
para-Nitroaniline is considered to be only slightly toxic on the basis of
single exposure animal tests, human experience has shown that man is much
more sensitive to methemoglobinemia caused by aromatic amino compounds than
the rat or the rabbit.Methemoglobinemia is a condition caused by changes in
the blood cells which decrease the oxygen-carrying capacity of the blood.
Cyanosis may occur and, as oxygen deficiency increases,there may be
associated headache, weakness, irritability, drowsiness, shortness of
breath, and unconsciousness. The appearance of methemoglobinemia may be
delayed 0 to 12 hours after exposure. Because of the high potential for
this material to cause methemoglobin formation, para-nitroaniline should be
considered HAZARDOUS by all routes of exposure and exposures should be
tightly controlled.
Inhalation:
Headache, coughing, dizziness, difficult breathing, nausea, vomiting,
increased heart rate, cyanosis, unconsciousness.
Ingestion:
Nausea, vomiting, increased heart rate, methemoglobinemia cyanosis, (bluish
discoloration of skin)
Skin Contact:
Not a skin irritant May be absorbed through the skin with possible systemic
effects.
Eye Contact:
Slight irritation, with discomfort, tearing, blurring of vision.
Chronic Exposure:
Liver damage, kidney damage, bone marrow, blood damage.
Aggravation of Pre-existing Conditions:
Liver disorders.
4. First Aid Measures
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Prompt action is
essential.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give
anything by mouth to an unconscious person. Get medical attention.
Skin Contact:
Immediately remove contaminated clothing and wash affected area thoroughly
with soap and water.
Eye Contact:
In case of eye contact, immediately flush with plenty of water for at least
15 minutes.
Note to Physician:
Absorption of this product into the body may lead to the formation of
methemoglobin that, in sufficient concentration, causes cyanosis. Since
reversion of methemoglobin to hemoglobin occurs spontaneously after
termination of exposure, moderate degrees of cyanosis need be treated only
by supportive measures such as bed rest and oxygen inhalation. Thorough
cleansing of the entire contaminated area of the body, including scalp and
nails, is of utmost importance. If cyanosis is severe, intravenous
injection of methylene blue, one milligram per kilogram of body weight, may
be of value. Cyanocobalamin (Vitamin B12), one milligram intramuscularly,
may speed recovery. Intravenous fluids and bloodtransfusions may be
indicated in very severe exposure.
5. Fire Fighting Measures
Fire:
Flash point: 199C (390F) CC
Explosion:
Combustible dust. This material, like most organic materials in powder
form, is capable of creating a dust explosion. Refer to NFPA pamphlet No.
654. "Standard for the Prevention of Fire and Dust Explosions in the
Chemical, Dye, Pharmaceutical and Plastics Industries" if the material is
to be reduced to or collected as a powder. Sensitive to static discharge.
Fire Extinguishing Media:
Water, dry chemical, foam or carbon dioxide.
Special Information:
Firefighters should wear proper protective equipment and self-contained
breathing apparatus with full facepiece operated in positive pressure mode.
Fire fighting equipment should be thoroughly decontaminated after use. This
material, as normally packaged and handled, can contain sufficient fines to
present a potential dust explosion hazard if a sufficient quantity of this
material is dispersed in air.
6. Accidental Release Measures
Wear self-contained breathing apparatus and full protective clothing. With
clean shovel, carefully place material into clean, dry container and cover;
remove from area. Flush spill area with water. Ventilate area.
7. Handling and Storage
Store in a cool place away from heated areas, sparks, and flame. Store in
a well ventilated area. Store away from incompatible materials. Keep
containers tightly closed and dry. Avoid contact with skin and eyes.
Avoid dust formation Protect from freezing. Use only in a chemical fume
hood. Do not breathe dust. Do not get in eyes, on skin, or on clothing.
Avoid prolonged or repeated exposure. Wash thoroughly after handling. Keep
it dry. Moisture causes nitration of organic materials and may result in
spontaneous ignition. Containers of this material may be hazardous when
empty since they retain product residues (dust, solids); observe all
warnings and precautions listed for the product.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
-OSHA Permissible Exposure Limit (PEL):
1 ppm (TWA) The PEL listed denotes PEL (skin).
-ACGIH Threshold Limit Value (TLV):
3 mg/m3 (TWA) The TLV listed denotes TLV (skin).
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee
exposures below the Airborne
Exposure Limits. Local exhaust ventilation is generally preferred because
it can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH
document, Industrial Ventilation, A Manual of Recommended Practices,
most recent edition, for details.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to the substance is apparent, consult
an industrial hygienist. For emergencies, or instances where the exposure
levels are not known, use a full-facepiece positive-pressure, air-supplied
respirator. WARNING: Air purifying respirators do not protect workers in
oxygen-deficient atmospheres.
Skin Protection:
Wear impervious protective clothing, including boots, gloves, lab coat,
apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection:
Use chemical safety goggles and/or full face shield where dusting or
splashing of solutions is possible. Maintain eye wash fountain and
quick-drench facilities in work area.
9. Physical and Chemical Properties
Appearance:
Yellow Powder.
Odor:
Faint amine odor.
Solubility:
Negligible (<0.1%)
Specific Gravity:
1.44
pH:
No information found.
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
332C (630F)
Melting Point:
149C (300F)
Vapor Density (Air=1):
4.77
Vapor Pressure (mm Hg):
Not applicable.
Evaporation Rate (BuAc=1):
No information found.
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, oxides of nitrogen.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizing agents, strong acids, strong reducing agents, strong
bases, alcohols, ketones, aldehydes.
Conditions to Avoid:
Heat, flame, other sources of ignition, moisture.
11. Toxicological Information
Reproductive Toxicity:
The compound does produce genetic damage in bacterial cell cultures but
does not produce genetic damage in animals. It does not produce heritable
genetic damage.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
p-Nitroaniline (100-01-6) No No None
12. Ecological Information
Environmental Fate:
No information found.
Environmental Toxicity:
Daphnia Magna: 48 Hr-LC50 = 20-30 ppm, slightly toxic. Rainbow Trout: 96
Hr-LC50 = 45 ppm, slightly toxic. Bluegill Sunfish: 96 Hr-LC50 = 80 ppm,
slightly toxic.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be handled as
hazardous waste and sent to a RCRA approved waste facility. Processing, use
or contamination of this product may change the waste management options.
State and local disposal regulations may differ from federal disposal
regulations.
Dispose of container and unused contents in accordance with federal, state
and local requirements.
14. Transport Information
Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: NITROANILINES
Hazard Class: 6.1
UN/NA: UN1661
Packing Group: II
Information reported for product/size: 100G
International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: NITROANILINES
Hazard Class: 6.1
UN/NA: UN1661
Packing Group: II
Information reported for product/size: 100G
International (Air, I.C.A.O.)
-----------------------------
Proper Shipping Name: NITROANILINES
Hazard Class: 6.1
UN/NA: UN1661
Packing Group: II
Information reported for product/size: 100G
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
p-Nitroaniline (100-01-6) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
p-Nitroaniline (100-01-6) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
p-Nitroaniline (100-01-6) No No Yes No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
p-Nitroaniline (100-01-6) 5000 P077 Yes
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No
Reactivity: Yes (Pure / Solid)
Australian Hazchem Code: 2X
Poison Schedule: No information found.
WHMIS:
This MSDS has been prepared according to the hazard criteria of
the Controlled Products Regulations (CPR) and the MSDS contains
all of the information required by the CPR.
16. Other Information
NFPA Ratings:
Health: 3 Flammability: 1 Reactivity: 3
Label Hazard Warning:
POISON! DANGER! HAZARDOUS SOLID AND DUST. HIGHLY TOXIC. RAPIDLY ABSORBED
THROUGH SKIN. CAUSES METHEMOGLOBINEMIA, DECREASING OXYGEN IN BLOOD.
COMBUSTIBLE DUST - EXPLOSION POTENTIAL. MAY BE FATAL IF SWALLOWED, INHALED,
OR ABSORBED THROUGH SKIN. HANDLE IN A FUME HOOD.
TARGET ORGAN(S): Lungs, heart, blood, liver.
Label Precautions:
Do not get in eyes, on skin, on clothing.
Do not breathe dust. Keep in tightly closed container. Use with adequate
ventilation. Wash thoroughly after handling. In case of fire, soak with
water. In case of spill, sweep up and remove. Flush spill area with water.
Label First Aid:
If swallowed, induce vomiting immediately as directed by medical personnel.
Never give anything by mouth to an unconscious person. If inhaled, remove to
fresh air. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. Prompt action is essential. In case of contact,
immediately flush eyes or skin with plenty of water for at least 15 minutes
while removing contaminated clothing and shoes. Wash clothing before reuse.
Product Use:
Laboratory Reagent.
Revision Information:
Pure. New 16 section MSDS format, all sections have been revised.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good
faith but makes no representation as to its comprehensiveness or accuracy. This
document is intended only as a guide to the appropriate precautionary handling
of the material by a properly trained person using this product. Individuals
receiving the information must exercise their independent judgment in
determining its appropriateness for a particular purpose. MALLINCKRODT BAKER,
INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED,
INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A
PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE
PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC.
WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS
INFORMATION.
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Prepared by: Strategic Services Division
Phone Number: (314) 539-1600 (U.S.A.)