International Chemical Safety Cards

HEXAMETHYLPHOSPHORIC TRIAMIDE ICSC: 0162
HEXAMETHYLPHOSPHORIC TRIAMIDE
Hexamethylphosphoramide
Hexamethylphosphamide
HMPA
C6H18N3OP/{(CH3)2N}3P(O)
Molecular mass: 179.2
CAS # 680-31-9
RTECS # TD0875000
ICSC # 0162
EC # 015-106-00-2

TYPES OF
HAZARD/
EXPOSURE
ACUTE HAZARDS/
SYMPTOMS
PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION


EXPOSURE
AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
  • INHALATION

  • Ventilation, local exhaust, or breathing protection.
    Refer for medical attention.
  • SKIN
  • MAY BE ABSORBED!
    Protective gloves. Protective clothing.
    Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
  • EYES

  • Safety spectacles or face shield.
    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
  • INGESTION

  • Do not eat, drink, or smoke during work.
    Rinse mouth. Refer for medical attention.
    SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
    Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place (extra personal protection: self-contained breathing apparatus).
    Ventilation along the floor.

    T symbol
    R: 45-46
    S: 53-45
    SEE IMPORTANT INFORMATION ON BACK
    ICSC: 0162 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993

    International Chemical Safety Cards

    HEXAMETHYLPHOSPHORIC TRIAMIDE ICSC: 0162

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    PHYSICAL STATE; APPEARANCE:
    COLOURLESS MOBILE LIQUID.

    PHYSICAL DANGERS:


    CHEMICAL DANGERS:
    The substance decomposes on heating or on burning producing toxic fumes including phosphorous oxides, nitrogen oxides.

    OCCUPATIONAL EXPOSURE LIMITS (OELs):
    TLV: ppm; mg/m3 A2 (skin) (ACGIH 1993).


    ROUTES OF EXPOSURE:
    The substance can be absorbed into the body by inhalation and through the skin.

    INHALATION RISK:
    No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C.

    EFFECTS OF SHORT-TERM EXPOSURE:
    The substance may cause effects on the lungs, kidneys and central nervous system , resulting in impaired functions and depression.

    EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
    The substance may have effects on the respiratory tract, kidneys and bone marrow. This substance is possibly carcinogenic to humans. May cause genetic damage in humans.
    PHYSICAL
    PROPERTIES
    Boiling point: 232°C
    Melting point: 5-7°C
    Relative density (water = 1): 1.03
    Solubility in water: very good
    Vapour pressure, Pa at 20°C: 4
    Relative vapour density (air = 1): 6.18
    Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
    Flash point: 105°C
    ENVIRONMENTAL
    DATA

    N O T E S
    Depending on the degree of exposure, periodic medical examination is indicated. Hexametapol is a trade name.
    ADDITIONAL INFORMATION


    ICSC: 0162 HEXAMETHYLPHOSPHORIC TRIAMIDE
    © IPCS, CEC, 1993
    IMPORTANT LEGAL NOTICE: Neither the CEC or the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use.