International Chemical Safety Cards

DIAZOMETHANE ICSC: 1256
DIAZOMETHANE
Azimethylene
Diazirine
CH2N2
Molecular mass: 42.04
CAS # 334-88-3
RTECS # PA7000000
ICSC # 1256
EC # 006-068-00-8

TYPES OF
HAZARD/
EXPOSURE
ACUTE HAZARDS/
SYMPTOMS
PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Extremely flammable. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames, NO sparks, and NO smoking.
Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out; in other cases extinguish with powder, carbon dioxide.
EXPLOSION Gas/air mixtures are explosive.
Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT expose to friction or shock. Prevent build-up of electrostatic charges (e.g., by grounding).
Combat fire from a sheltered position.
EXPOSURE
AVOID ALL CONTACT!
IN ALL CASES CONSULT A DOCTOR!
  • INHALATION
  • Headache. Laboured breathing. Shortness of breath. Sore throat. Vomiting. Malaise. Symptoms may be delayed (see Notes).
    Ventilation, local exhaust, or breathing protection.
    Fresh air, rest. Half-upright position. Artificial respiration if indicated. Refer for medical attention.
  • SKIN
  • Redness. Burning sensation. Pain. Serious frostbite.
    Cold-insulating gloves.
    ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention. Wear protective gloves when administering first aid.
  • EYES
  • Redness. Pain.
    Face shield or eye protection in combination with breathing protection.
    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
  • INGESTION

  • Do not eat, drink, or smoke during work.

    SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
    Evacuate danger area! Consult an expert! Ventilation (extra personal protection: complete protective clothing including self-contained breathing apparatus).
    Solutions of diazomethane should not be stored (see Notes).

    T symbol
    R: 45
    S: 53-45
    SEE IMPORTANT INFORMATION ON BACK
    ICSC: 1256 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993

    International Chemical Safety Cards

    DIAZOMETHANE ICSC: 1256

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    PHYSICAL STATE; APPEARANCE:
    YELLOW GAS.

    PHYSICAL DANGERS:
    The gas is heavier than air and may travel along the ground; distant ignition possible.

    CHEMICAL DANGERS:
    May explosively decompose on shock, friction, or concussion. May explode on heating at 100C, or on contact with rough surfaces or if impurities or solids are present in the undiluted liquid or in the concentrated solutions, or under high intensity lighting. Contact with alkali metals and calcium sulfate causes explosions.

    OCCUPATIONAL EXPOSURE LIMITS (OELs):
    TLV: 0.2 ppm; 0.34 mg/m3 (ACGIH 1993-1994).


    ROUTES OF EXPOSURE:
    The substance can be absorbed into the body by inhalation.

    INHALATION RISK:
    A harmful concentration of this gas in the air will be reached very quickly on loss of containment.

    EFFECTS OF SHORT-TERM EXPOSURE:
    The substance is very corrosive to the eyes, the skin and the respiratory tract. Inhalation of the vapour may cause lung oedema (see Notes). Inhalation of the vapour may cause asthmatic reactions (see Notes). The liquid may cause frostbite. Exposure above the OEL may result in death. Medical observation is indicated.

    EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
    Repeated or prolonged inhalation exposure may cause asthma. This substance is possibly carcinogenic to humans.
    PHYSICAL
    PROPERTIES
    Boiling point: -23C
    Melting point: -145C
    Relative density (water = 1): 1.45
    Solubility in water: reaction
    Relative vapour density (air = 1): 1.4
    Flash point: Flammable Gas
    Auto-ignition temperature: 100C (explosion)C
    ENVIRONMENTAL
    DATA

    N O T E S
    Because of its toxicity and its explosive nature, diazomethane is freshly prepared in situ and used in solution of ether or dioxane. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered. The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. The relation between odour and the occupational exposure limit cannot be indicated. The recommendations on this Card also apply to concentrated solutions of diazomethane.
    ADDITIONAL INFORMATION


    ICSC: 1256 DIAZOMETHANE
    © IPCS, CEC, 1993
    IMPORTANT LEGAL NOTICE: Neither the CEC or the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use.