International Chemical Safety Cards

ISONIAZID ICSC: 1258
ISONIAZID
Isonicotinic hydrazide
4-pyridinecarboxylic acid, hydrazide
C6H7N3O
Molecular mass: 137.1
CAS # 54-85-3
RTECS # NS1751850
ICSC # 1258

TYPES OF
HAZARD/
EXPOSURE
ACUTE HAZARDS/
SYMPTOMS
PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Powder, water spray, foam, carbon dioxide.
EXPLOSION


EXPOSURE
PREVENT DISPERSION OF DUST!

  • INHALATION

  • Local exhaust or breathing protection.
    Fresh air, rest.
  • SKIN

  • Protective gloves.
    Remove contaminated clothes. Rinse and then wash skin with water and soap.
  • EYES

  • Safety spectacles.
    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
  • INGESTION
  • Confusion. Convulsions. Nausea. Weakness. Ataxia. Hallucinations.
    Do not eat, drink, or smoke during work.
    Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention.
    SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
    Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place (extra personal protection: P2 filter respirator for harmful particles).
    Cool. Well closed.

    SEE IMPORTANT INFORMATION ON BACK
    ICSC: 1258 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993

    International Chemical Safety Cards

    ISONIAZID ICSC: 1258

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    PHYSICAL STATE; APPEARANCE:
    WHITE CRYSTALLINE POWDER.

    PHYSICAL DANGERS:


    CHEMICAL DANGERS:
    The substance decomposes on heating and on burning producing toxic fumes including nitrogen oxides.

    OCCUPATIONAL EXPOSURE LIMITS (OELs):
    TLV not established.


    ROUTES OF EXPOSURE:
    The substance can be absorbed into the body by ingestion.

    INHALATION RISK:
    Evaporation at 20C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

    EFFECTS OF SHORT-TERM EXPOSURE:
    The substance may cause effects on the nervous system and kidneys , resulting in disorientation, lethargy, coma, metabolic acidosis. Exposure at high level could cause death. Exposure may result in unconsciousness.

    EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
    The substance may have effects on the central nervous system and the liver , resulting in tissue lesions and impaired functions.
    PHYSICAL
    PROPERTIES
    Melting point: 170-173C
    Solubility in water, g/100 ml at 20C: 12.5
    ENVIRONMENTAL
    DATA

    N O T E S
    Many trade names are known for this compound.
    ADDITIONAL INFORMATION


    ICSC: 1258 ISONIAZID
    © IPCS, CEC, 1993
    IMPORTANT LEGAL NOTICE: Neither the CEC or the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use.