International Chemical Safety Cards

PROPIONIC ANHYDRIDE ICSC: 0558
PROPIONIC ANHYDRIDE
Propanoic anhydride
Methylacetic anhydride
Propanoic acid anhydride
C6H10O3 / (CH3CH2CO)2O
Molecular mass: 130.2
CAS # 123-62-6
RTECS # UF9100000
ICSC # 0558
UN # 2496
EC # 607-010-00-X

TYPES OF
HAZARD/
EXPOSURE
ACUTE HAZARDS/
SYMPTOMS
PREVENTION FIRST AID/
FIRE FIGHTING
FIRE Combustible.
NO open flames.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION Above 63C explosive vapour/air mixtures may be formed.
Above 63C use a closed system, ventilation.

EXPOSURE
PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!

  • INHALATION
  • Sore throat. Cough. Burning sensation. Shortness of breath. Symptoms may be delayed (see Notes).
    Ventilation, local exhaust, or breathing protection.
    Fresh air, rest. Artificial respiration if indicated. Refer for medical attention.
  • SKIN
  • Pain. Blisters.
    Protective gloves. Protective clothing.
    Remove contaminated clothes. Rinse skin with plenty of water or shower.
  • EYES
  • Redness. Pain. Severe deep burns.
    Face shield, or eye protection in combination with breathing protection.
    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
  • INGESTION
  • Burning sensation. Abdominal pain. Shock or collapse. Sore throat.
    Do not eat, drink, or smoke during work.
    Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Refer for medical attention.
    SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING
    Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place (extra personal protection: chemical suit including self-contained breathing apparatus).
    Separated from acids, bases, oxidants, food and feedstuffs. Dry. Ventilation along the floor.
    Do not transport with food and feedstuffs.
    C symbol
    R: 34
    S: (1/2)-26-45
    UN Hazard Class: 8
    UN Packing Group: III

    SEE IMPORTANT INFORMATION ON BACK
    ICSC: 0558 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities © IPCS CEC 1993

    International Chemical Safety Cards

    PROPIONIC ANHYDRIDE ICSC: 0558

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    PHYSICAL STATE; APPEARANCE:
    COLOURLESS LIQUID , WITH PUNGENT ODOUR.

    PHYSICAL DANGERS:
    The vapour is heavier than air.

    CHEMICAL DANGERS:
    The substance decomposes on contact with water producing corrosive propionic acid. Reacts violently with acids, bases and oxidants causing fire and explosion hazard.

    OCCUPATIONAL EXPOSURE LIMITS (OELs):
    TLV not established.


    ROUTES OF EXPOSURE:
    The substance can be absorbed into the body by inhalation of its vapour or its aerosol, and by ingestion.

    INHALATION RISK:
    No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20C.

    EFFECTS OF SHORT-TERM EXPOSURE:
    Corrosive. The substance is corrosive to the eyes, the skin and the respiratory tract. Inhalation of vapour or aerosol may cause lung oedema (see Notes). The effects may be delayed. Medical observation is indicated.


    PHYSICAL
    PROPERTIES
    Boiling point: 167C
    Melting point: -45C
    Relative density (water = 1): 1.01
    Solubility in water: reaction
    Vapour pressure, kPa at 20C: 100
    Relative vapour density (air = 1): 4.5
    Relative density of the vapour/air-mixture at 20C (air = 1): 4.4
    Flash point: 63C
    Auto-ignition temperature: 285C
    Explosive limits, vol% in air: 1.3-9.5
    ENVIRONMENTAL
    DATA

    N O T E S
    The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered.
    Transport Emergency Card: TEC (R)-80G20
    NFPA Code: H3; F2; R1;
    ADDITIONAL INFORMATION


    ICSC: 0558 PROPIONIC ANHYDRIDE
    © IPCS, CEC, 1993
    IMPORTANT LEGAL NOTICE: Neither the CEC or the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use.