E R SQUIBB MEDATOPE DIV -- PLANTINOL 50 MG CISPLATIN/VIAL -- 6505-01-074-7590
===================== Product Identification ===================== Product ID:PLANTINOL 50 MG CISPLATIN/VIAL MSDS Date:01/07/1993 FSC:6505 NIIN:01-074-7590 MSDS Number: CDFSN === Responsible Party === Company Name:E R SQUIBB MEDATOPE DIV Address:5 GORDIS RD BLDG 124 Box:191 City:NEW BRUNSWICK State:NJ ZIP:08903-5000 Country:US Info Phone Num:800-332-2056/908-519-3843 Emergency Phone Num:908-519-3843/609-921-4081 CAGE:GO533 === Contractor Identification === Company Name:E R SQUIBB MEDATOPE DIV Address:5 GORDIS RD BLDG 124 Box:191 City:NEW BRUNSWICK State:NJ ZIP:08903 Country:US Phone:609-921-4081 CAGE:4T649 Company Name:E R SQUIBB MEDATOPE DIV Address:5 GORDIS RD BLDG 124 Box:191 City:NEW BRUNSWICK State:NJ ZIP:08903-5000 Country:US Phone:800-332-2056/908-519-3843 CAGE:GO533 ============= Composition/Information on Ingredients ============= Ingred Name:CIS-DIAMINEDICHLOROPLATINUM CAS:15663-27-1 RTECS #:TP2450000 Fraction by Wt: 5% OSHA PEL:0.002 MG(PT)/CUM Ingred Name:MINNITOL, D- (MANNA SUGAR); MANNITOL CAS:69-65-8 RTECS #:OP2060000 Fraction by Wt: >1% Ingred Name:SODIUM CHLORIDE *96-4* CAS:7647-14-5 RTECS #:VZ4725000 Fraction by Wt: >1% Ingred Name:HYDROCHLORIC ACID, HYDROGEN CHLORIDE, MURIATIC ACID HYDROCHLORIDE CAS:7647-01-0 RTECS #:MW4025000 Other REC Limits:7 PPM OSHA PEL:5 PPM ACGIH TLV:C 11 MG/CUM EPA Rpt Qty:5000 LBS DOT Rpt Qty:5000 LBS ===================== Hazards Identification ===================== LD50 LC50 Mixture:ORAL LD50(RAT): 25.8 MG/KG Routes of Entry: Inhalation:NO Skin:NO Ingestion:NO Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO Health Hazards Acute and Chronic:CISPLATIN-A CYTOTOXIC DRUG. INHALATION: TRANSIENT BRONCHIAL IRRITANT. SKIN: FROM OPENED VIAL; MILD IRRITANT. EYES: CONJUNCTIVITIS. INTRAVENOUS EXPOSURE MAY CAUSE ANAPHYLACTOID REACTIONS. MAY CAUSE KID NEY TOXICITY/PERIPHERAL NEUROPATHY/REVERSIBLE HEMATOLOGIC EFFECTS. POTENTIAL CARCINOGEN/TERATOGEN/REPRODUCTIVE EFFECTOR. Explanation of Carcinogenicity:NONE Effects of Overexposure:CISPLATIN: IRRITATION, RASH, NAUSEA, VOMITING, FACIAL EDEMA, FLUSHING, WHEEZING, RESPIRATORY DIFFICULTY, TACHYCARDIA, HYPOTENSION, ELECTROLYTE DISTURBANCES, OTOTOXICITY Medical Cond Aggravated by Exposure:KIDNEY DISEASES, HEARING DISORDERS, NEUROLOGICAL DISEASES & ANEMIA/OTHER FORMS OF BONE MARROW SUPPRESSION. ======================= First Aid Measures ======================= First Aid:INGESTION: INDUCE VOMITING IF CONSCIOUS & NOT CONVULSIVE. NEVER GIVE ANYTHING BY MOUTH IF UNCONSCIOUS. INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NECESSARY. SKIN: IMMEDIATELY FLUSH W/LARGE AM OUNTS OF WATER. USE SOAP. EYES: FLUSH W/RUNNING WATER FOR 15 MINS. OBTAIN MEDICAL ATTENTION IN ALL CASES. ===================== Fire Fighting Measures ===================== Extinguishing Media:UNLIKELY TO BURN IN VIAL. IN CASE OF FIRE, FLOOD W/WATER Fire Fighting Procedures:WEAR SCBA, FLAME & CHEMICAL RESISTANT CLOTHING, BOOTS & GLOVES. EVACUATE PERSONNEL TO UPWIND. COOL CONTAINERS W/WATER FROM A MAXIMUM DISTANCE. ================== Accidental Release Measures ================== Spill Release Procedures:SMALL: WIPE W/ABSORBENT GAUZE PADS. CLEAN USING DETERGENT & WATER. COVER W/GAUZE PADS/PAPER TOWEL. SOAK W/WATER & WIPE UP. LARGE: COVER LIQUID W/ABSORBENT SHEETS/SPILL-CONTROL PADS/PILLOWS. CLEAN USIN G DETERGENTS & WATER. ====================== Handling and Storage ====================== Handling and Storage Precautions:SHOULD BE STORED AT ROOM TEMP 59-77F. DON'T REFRIGERATE. PROTECT FROM LIGHT. SEE RELEVANT GUIDANCE FOR HANDLING CYTOTOXIC MATERIALS. Other Precautions:DON'T ALLOW PLATINOL TO CONTACT ALUMINUM. ALUMINUM REACTS W/FORMULATED PLATINOL, CAUSING PRECIPITATE FORMATION & LOSS OF POTENCY. ============= Exposure Controls/Personal Protection ============= Respiratory Protection:WHEN ENGINEERING CONTROLS AREN'T SUFFICIENT TO CONTROL EXPOSURE, WEAR APPROVED RESPIRATOR W/HIGH EFFICIENCY DUST FILTER/POWDERED AIR-PURIFYING RESPIRATOR; SELF CONTAINED BREATHING APPARATUS. Ventilation:LOCAL MECHANICAL EXHAUST TO MINIMIZE EXPOSURE. BIOLOGICAL SAFETY CABINET SHOULD BE USED FOR PREPARATION OF THIS DRUG. Protective Gloves:SURGICAL LATEX/POLYVINYL CHLORIDE Eye Protection:CHEMICAL SAFETY GOGGLES Other Protective Equipment:IMPERVIOUS DISPOSABLE COVERALLS W/CLOSED FRONT, LONG SLEEVES & ELASTIC CUFFS & BOOTS TO PROTECT FROM DUST/SPLASHES/SPRAY Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING & SHOES BEFORE REUSE. Supplemental Safety and Health GLOVES SHOULD BE CHANGED REGULARLY & REMOVED IMMEDIATELY AFTER OVERT CONTAMINATION. DOUBLE GLOVING IS RECOMMENDED FOR CLEANING. MEDICAL SURVEILLANCE RECOMMENDATION: A PRE-PLACEMENT PHYSICAL EXAMINATIO N & HISTORY FOR EMPLOYEES W/POTENTIAL EXPOSURE TO PLATINOL IS RECOMMENDED. PH: 3.5-5.5 (RECONSTITUTED SOLUTIONS). ================== Physical/Chemical Properties ================== Melt/Freeze Pt:M.P/F.P Text:518F pH:(SUPP) Solubility in Water:1 MG/ML Appearance and Odor:WHITE LYOPHILIZED POWDER WHICH IS PACKAGED IN VIALS ================= Stability and Reactivity Data ================= Stability Indicator/Materials to Avoid:YES ALUMINUM Stability Condition to Avoid:REFRIGERATION, LIGHT Hazardous Decomposition Products:CO, CARBON OXIDES, HYDROGEN CHLORIDE, NITROGEN OXIDES ==================== Disposal Considerations ==================== Waste Disposal Methods:TREAT PRODUCT & CONTAMINATED MATERIALS AS HAZARDOUS MATERIAL. INCINERATION IS RECOMMENDED. DISPOSE OF IN ACCORDANCE W/LOCAL, STATE & FEDERAL REGULATIONS. 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