EMS CATALOG NO: 11820 
EMS PRODUCT:  Butoxy Ethanol
DATE:   05/15/95
PAGE NUMBER:  One of 10


MATERIAL SAFETY DATA SHEET


The information contained herein is based on data considered
accurate. However, no warranty is expressed or implied
regarding the accuracy of these data or the results to obtained
from the use thereof.

Electron Microscopy Sciences assumes no responsibility for
personal injury or property damage to vendees, users or
third parties caused by the material. Such vendees or users
assume all risks associated with the use of the material.


ELECTRON MICROSCOPY SCIENCES
321 MORRIS ROAD
P.O. BOX 251
FORT WASHINGTON, PA 19034 24 HOUR EMERGENCY PHONE NUMBER
(215) 646-1566 CHEMTREC: (800) 424-9300
_________________________________________________________________

FOR PRODUCT AND SALES INFORMATION
_________________________________________________________________

CONTACT ELECTRON MICROSCOPY SCIENCES OFFICE ABOVE.

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PRODUCT IDENTIFICATION
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PRODUCT NAME: 2-Butoxy Ethanol

CAS NUMBER: 111-76-2

TRADE NAMES/
SYNONYMS: Butyl Cellosolve, Ethanol, 2-Butoxy-; Butyl Oxitol; 
Ethylene Glycol monobutyl Ether; 2-Butoxyethanol; Beta-Butoxyethanol;
Butyl Glycol; Ethylene Glycol Butyl Ether; Ethylene Glycol N-Butyl
Ether; Dowanol EB; Glycol Butyl Ether; Glycol Monobutyl Ether; Monobutyl
Glycol Ether; Gapcol EB; Butyl Monoether Glycol; Ethylene Glycol
Mono-N-Butyl Ether; Ektasolve EB; Solvent, Thinner and Screen Wash
(Naz-Dar Co.); Screen Ink Reducer (Colonial Printing Ink Co.,);
UN 2369; C6H14O2; OHS03540 

CHEMICAL FAMILY: Ether, Aliphatic


MOLECULAR FORMULA: C4H9OCH2CH2OH

MOLECULAR WEIGHT: 118.18

CERCLA RATINGS (SCALE 0-3): NFPA RATINGS (0-4):
HEALTH=3 HEALTH=2
FIRE=2 FIRE=2
REACTIVITY=0 REACTIVITY-0
PERSISTENCE=0
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COMPONENTS AND CONTAMINANTS
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COMPONENT: Butyl Cellosolve 100%

OTHER CONTAMINANTS: None

EXPOSURE LIMITS: BUTYL CELLOSOLVE (ETHYLENE GLYCOL MONOBUTYL ETHER):

25 ppm (120 mg/m3) OSHA TWA (SKIN)
25 ppm (120 mg/m3) ACGIH TWA (SKIN)
25 ppm (120 mg/m3) NIOSH RECOMMENDED TWA (SKIN)
20 ppm (100 mg/m3) DFG MAK TWA (SKIN)
40 ppm (200 mg/m3) DFG MAK 30 Minute peak, Average value, 4
Times/Shift

MEASUREMENT METHOD:

Charcoal Tube; Methanol/Methylene Chloride; Gas Chromatography
with Flame Ionization Detection; (NIOSH Vol. III # 1403, Alcohols
IV).
Subject to SARA Section 313 Annual Toxic Chemical Release reporting.
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PHYSICAL DATA
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DESCRIPTION: Colorless liquid with a mild, ethereal odor.
BOILING POINT: 340oF/171oC
MELTING POINT: -94oF/-70oC
SPECIFIC GRAVITY: 0.9015
VAPOR PRESSURE: 0.76 mm Hg at 20oC
EVAPORATION RATE: 0.06 (Butyl Acetate=1)
SOLUBILITY IN H20: Soluble
VAPOR DENSITY: 4.1
VISCOSITY: 3.5 cs at 25oC
SOLVENT SOLUBILITY: Soluble in alcohol, ether, most organic solvents,
mineral oil.



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FIRE AND EXPLOSION DATA
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FIRE AND EXPLOSION HAZARD:

Moderate fire hazard when exposed to heat or flame. Vapors are
heavier than air and may travel a considerable distance to a source
of ignition and flash back. Vapor-air mixtures are explosive above
flash point.

FLASH POINT: 143oF/62oC (CC)
UPPER EXPLOSIVE LIMIT: 12.7% at 275oF
LOWER EXPLOSIVE LIMIT: 1.1% at 200oF
AUTOIGNITION TEMP.: 460oF/238oC
FLAMMABILITY CLASS (OSHA): IIIA

FIREFIGHTING MEDIA:

Dry chemical, carbon dioxide, water spray or alcohol-resistant 
foam (1990 Emergency Response Guidebook, DOT P 5800.5).

For larger fires, use water spray, fog or alcohol-resistant foam
(1990 Emergency Response Guidebook, DOT P 5800.5).

ALCOHOL FOAM: (NFPA 325m, Fire hazard properties of flammable liquids,
gases, and volatile solids, 1984). 

FIREFIGHTING:

Move container from fire area if you can di it without risk. 
Apply cooling water to sides of containers that are exposed to flame
until well after fire is out. Stay away from storage tank ends.
For massive fire in cargo area, use unmanned hose holder or monitor
nozzles; if this is impossible, withdraw from area and let fire
burn. Withdraw immediately in case of rising sound from venting
safety device or any discoloration of tank due to fire. Isolate
for 1/2 mile in all directions if tank, rail car or tank truck is
involved in fire. (1990 Emergency Response Guidebook, DOT P 5800.5,
Guide Page 26).

Extinguish only if flow can be stopped; use flooding amounts of
water as a fog, solid streams may be ineffective. Cool containers
with flooding amounts of water, apply from as far a distance as
possible. Avoid breathing vapors, keep upwind.
Alcohol foam (NFPA Fire Protection Guide on Hazardous Material,
Eighth Edition).
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TRANSPORTATION DATA
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DOT HAZARD CLASSIFICATION 49CFR172.101: Combustible liquid

DOT LABELING REQUIREMENTS 49CFR172.101
AND SUBPART E: None

DOT PACKAGING REQUIREMENTS: None

EXCEPTIONS: 49CFR173.118A
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TOXICITY
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BUTYL CELLOSOLVE (ETHYLENE GLYCOL MONOBUTYL ETHER):

IRRITATION DATA: 500 mg open skin-rabbit mild; 
18 mg eye-rabbit; 
100 mg/24 hours eye-rabbit moderate.

TOXICITY DATA:

195 ppm/8 hours inhalation-human TCLO; 100 ppm inhalation-human
TCLO; 700 ppm/7 hours inhalation-mouse LC50; 220 mg/kg skin-
rabbit LD50; 220 mg/kg skin-guinea pig LD50; 600 mg/kg oral-woman
TDLO; 470 mg/kg oral-rat LD50; 1230 mg/kg oral-mouse LD50; 300 mg/kg
oral-rabbit LD50; 1200 mg/kg oral-guinea pig LD50; 500 mg/kg subcutaneous-
mouse LDLO; 340 mg/kg intravenous-rat LD50; 1130 mg/kg intravenous-mouse
LD50; 280 mg/kg intravenous-rabbit
LD50; 220 mg/kg intraperitoneal-rat LD50; 536 mg/kg intr-
aperitoneal-mouse LD50; 220 mg/kg intraperitoneal-rabbit LD50; 
1500 mg/kg unreported-mammal LD50; reproductive effects data (RTECS).

CARCINOGEN STATUS: None

LOCAL EFFECTS: Irritant - inhalation, skin, eye.

ACUTE TOXICITY LEVEL: Toxic by inhalation, dermal absorption, ingestion.
TARGET EFFECTS:

Central nervous system depressant; nephrotoxin; hemolytic agent.
Poisoning may also affect the liver.
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HEALTH EFFECTS AND FIRST AID
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INHALATION: Irritant/narcotic/hemolytic agent/nephrotoxin/toxic.
700 ppm immediately dangerous to life or health.

ACUTE EXPOSURE:

Inhalation of vapors may cause irritation of the upper respiratory
tract and dyspnea. Some cellosolves may cause vomiting, nausea,
diarrhea, anemia, possible abdominal and lumbar pain, and symptoms
of central nervous system depression including headache, dizziness,
drowsiness, weakness, tremors, and narcosis. Severe exposures may
result in anorexia, weight loss, apathy, visceral congestion, hemorrhaging
of the lungs, and liver and kidney damage. Kidney effects may include
transient polyuria, albuminuria, hematuria, hemoglobinuria, oliguria
progressing to anuria, and acute renal failure. Effects on the 
blood may include erythropenia, reticulocytosis, leukocytosis, granulocytosis,
and increased erythrocyte fragility which may result in hemolysis.
Pulmonary edema and bone marrow depression
have also been reported. Inhalation of 700 ppm/7 hours resulted
in death in mice due to lung and kidney injury.

CHRONIC EXPOSURE:

Repeated or prolonged exposure to vapor concentrations would be
expected to cause irritation of the respiratory tract, narcosis, 
and liver and kidney damage in humans. In animals, repeated exposures
to 100-400 ppm may cause visceral effects and mild hemolytic anemia;
overexposure to vapors may result in fatigue and lethargy, headache,
nausea, anorexia, and tremor; and overexposure to high concentrations
may result in liver and kidney injury, hemoglobinuria, greatly increased
erythrocyte fragility, pulmonary hemorrhage, and death from renal
failure.
Effects on the female reproductive system, fertility, and
specific developmental abnormalities have been reported
from exposure of pregnant rats and rabbits to butyl cellosolve.

FIRST AID:

Remove from exposure area to fresh air immediately. If breathing
has stopped, perform artificial respiration. Keep person warm and
at rest. Treat symptomatically and supportively. Get medical attention
immediately.

SKIN CONTACT: Irritant/narcotic/hemolytic agent/nephrotoxic/toxic.

ACUTE EXPOSURE:

Direct contact with the liquid may cause irritation with redness.
Butyl cellosolve may be rapidly absorbed through intact skin to
cause nausea, vomiting, diarrhea, anemia, abdominal and lumbar pain,
and symptoms of central nervous system depression including headache,
drowsiness, dizziness, weakness, tremors, and narcosis. Severe
exposures may result in anorexia, weight loss,
apathy, visceral congestion, hemorrhaging of the lungs, and liver
and kidney damage. Kidney effects may include transient poly-
uria, albuminuria, hematuria, hemoglobinuria, oliguria progressing
to anuria, and acute renal failure. Effects on the blood may
include erythropenia, reticulocytosis, leukocytosis, granu-
locytosis, and increased erythrocyte fragility which may result
in
hemolysis. Pulmonary edema and bone marrow depression have also
been reported.

CHRONIC EXPOSURE:

Repeated or prolonged contact may cause defatting of the skin, 
dermatitis, and symptoms as in acute exposure.

FIRST AID:

Remove contaminated clothing and shoes immediately. Wash affected
area with soap or mild detergent and large amounts of water until
no evidence of chemical remains (approximatley 15-20 minutes). 
Get medical attention immediately.

EYE CONTACT: Irritant

ACUTE EXPOSURE:

Exposure to vapor concentrations of > 100 ppm may cause irritation
with mild pain, redness, and lacrimation. Direct
contact with the liquid caused irritation with reddening and swelling
of the conjunctiva, pain, and slight transitory corneal clouding
in rabbits. The degree of injury was graded 4 on a scale of 1-10
after 24 hours.

CHRONIC EXPOSURE:

Repeated or prolonged exposure may cause conjunctivitis.

FIRST AID:

Wash eyes immediately with large amounts of water or normal saline,
occasionally lifting upper and lower lids, until no evidence of
chemical remains (approximately 15-20 minutes). Get medical attention
immediately.

INGESTION: Narcotic/hemolytic agent/nephrotoxic/toxic.

ACUTE EXPOSURE:

May cause sour taste, tongue numbness, nausea, vomiting, diarrhea,
abdominal and lumbar pain, and effects on the central nervous system
including headache, drowsiness, dizziness, weakness, tremors, and
narcosis. Severe exposures may result in anorexia, weight loss,
apathy, visceral congestion, hemorrhaging of the lungs, and liver
and kidney damage. Kidney affects may include transient polyuria,
albuminuria, hematuria, hemo-
globinuria, oliguria progressing to anuria, and acute renal effects
on the blood which may include erythropenia, reticulocytosis, leukocytosis,
granulocytosis, and increased erythrocyte fragility which may result
in hemolysis. Pulmonary edema and bone marrow depression have also
been reported. 
Animals given fatal doses died from narcosis when death was prompt;
delayed deaths resulted from congested lungs and severe kidney damage.

CHRONIC EXPOSURE:

Repeated or prolonged ingestion may cause growth depression, increased
liver and kidney damage, and effects as in acute
exposure. Delayed deaths in animals are generally a result of 
lung congestion and/or renal failure. Effects on fertility have 
been reported from exposure of pregnant mice to butyl cellosolve.

FIRST AID:

Remove by gastric lavage or emesis. Maintain blood pressure and
airway. Give oxygen if respiration is depressed. Do not perform
gastric lavage or emesis if victim is unconscious. Get medical 
attention immediately (Dreisbach, Handbook of Poisoning, 11th Ed.).
Administration of gastric lavage of oxygen should be
performed by qualified medical personnel.

ANTIDOTE: No specific antidote. Treat symptomatically and supportively.
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REACTIVITY
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REACTIVITY: Stable under normal temperatures and pressures.

INCOMPATIBILITIES:

CAUSTICS (STRONG): Decomposition.
OXIDIZERS (STRONG): Fire and explosion hazard.

DECOMPOSITION: Thermal decomposition products may include toxic oxides
of carbon.

POLYMERIZATION:

Hazardous polymerization has not been reported to occur under 
normal temperatures and pressures.

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STORAGE AND DISPOSAL
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Observe all Federal, State and local regulations when storing or disposing
of this substance. For assistance, contact the district director
of the Environmental Protection Agency.

STORAGE: Store in accordance with 29 CFR 1910.106.

BONDING AND GROUNDING:

Substances with low electroconductivity, which may be ignited by
electrostatic sparks, should be stored in containers which meet 
the bonding and grounding guidelines specified in NFPA 77-1983, 
Recommended Practice on Static Electricity.

STORE AWAY FROM INCOMPATIBLE SUBSTANCES.
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CONDITIONS TO AVOID
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Avoid contact with heat, sparks, flames, or other sources of ignition.
Vapors may be explosive and poisonous; do not allow unnecessary personnel.
Do not overheat containers; containers may violently rupture and travel
a considerable distance in heat of fire.
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SPILL AND LEAK PROCEDURES
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OCCUPATIONAL SPILL:

Shut off ignition sources. Stop leak if you can do it
without risk. Use water spray to reduce vapors. For small
spills, take up with sand or other absorbent material and
place into containers for later disposal. For larger
spills, dike far ahead of spill for later disposal.
No smoking, flames or flares in hazard area! Keep
Unnecessary people away; isolate hazard area and deny entry.
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PROTECTIVE EQUIPMENT
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VENTILATION:

Provide local exhaust or process enclosure ventilation to meet 
published exposure limits.

RESPIRATOR:

The following respirators and maximum use concentrations are 
recommendations by the U.S. Department of Health and Human Services,
NIOSH Pocket Guide to Chemical Hazards; NIOSH Criteria Documents
or by the U.S. Department of Labor, 29CFR1910 Subpart Z.

The specific respirator selected must be based on contamination
levels found in the work place, must not exceed the working limits
of the respirator and be jointly approved by the National Institute
for Occupational Safety and Health and the Mine Safety and Health
Administration (NIOSH-MSHA).

BUTYL CELLOSOLVE:

250 ppm: Any supplied-air respirator.
Any self-contained breathing apparatus.

625 ppm: Any powered air-purifying respirator with organic vapor
cartridge(s).
Any supplied-air respirator operated in a continuous flow mode.

700 ppm: Any air-purifying full facepiece respirator (gas mask) with
a chin-style or front-or back-mounted organic vapor canister.
Any chemical cartridge respirator with a full facepiece and organic
vapor cartridge(s).
Any supplied-air respirator with a full facepiece.
Any self-contained breathing apparatus with a full facepiece.
ESCAPE:

Any air-purifying full facepiece respirator (gas mask) with a 
chin-style or front-or back-mounted organic vapor canister.
Any appropriate escape-type self-contained breathing apparatus.

FORE FIREFIGHTING AND OTHER IMMEDIATELY DANGEROUS TO LIFE AND HEALTH
CONDITIONS:

Self-contained breathing apparatus with full facepiece operated
in pressure demand or other positive pressure mode.

Supplied-air respirator with full facepiece and operated in pressure-demand
or other positive pressure mode in combination with an auxiliary
self-contained breathing apparatus operated in pressure-demand or
other positive pressure mode.

CLOTHING:

Employee must wear appropriate protective (impervious) clothing
and equipment to prevent any possibility of skin contact with this
substance.

GLOVES:

Employee must wear appropriate protective gloves to prevent contact
with this substance.

EYE PROTECTION:

Employee must wear splash-proof or dust-resistant safety goggles
and a faceshield to prevent contact with this substance.

EMERGENCY WASH FACILITIES:

Where there is any possibility that an employee's eyes and/or 
skin may be exposed to this substance, the employer should provide
an eye wash fountain and quick drench shower within the immediate
work area for emergency use.